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Simvastatin Treatment Protects Myocardium in Noncoronary Artery Cardiac Surgery by Inhibiting Apoptosis Through miR-15a-5p Targeting.

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Title: Simvastatin Treatment Protects Myocardium in Noncoronary Artery Cardiac Surgery by Inhibiting Apoptosis Through miR-15a-5p Targeting.
Authors: Zhou L; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China., Liu X; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China., Wang ZQ; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China., Li Y; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China., Shi MM; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China., Xu Z; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China., Ou ZJ; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.; Division of Hypertension and Vascular Diseases, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China., Li HM; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China., Cheng TP; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China., Jian YP; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China., Zhang W; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China., Liu C; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.; Department of Cardiology, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China., Zhang X; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China., Quon MJ; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD., Zhang CX; Department of Biomedical Engineering, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL., Xu YQ; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China., Wang ZP; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China., Ou JS; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, P.R. China.
Source: Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2018 Oct; Vol. 72 (4), pp. 176-185.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Print Cited Medium: Internet ISSN: 1533-4023 (Electronic) Linking ISSN: 01602446 NLM ISO Abbreviation: J Cardiovasc Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Simvastatin Treatment Protects Myocardium in Noncoronary Artery Cardiac Surgery by Inhibiting Apoptosis Through miR-15a-5p Targeting.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+ZQ%22">Wang ZQ</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Shi+MM%22">Shi MM</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Ou+ZJ%22">Ou ZJ</searchLink>; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.; Division of Hypertension and Vascular Diseases, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+HM%22">Li HM</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Cheng+TP%22">Cheng TP</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Jian+YP%22">Jian YP</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.; Department of Cardiology, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Quon+MJ%22">Quon MJ</searchLink>; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Zhang+CX%22">Zhang CX</searchLink>; Department of Biomedical Engineering, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL.<br /><searchLink fieldCode="AU" term="%22Xu+YQ%22">Xu YQ</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+ZP%22">Wang ZP</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.<br /><searchLink fieldCode="AU" term="%22Ou+JS%22">Ou JS</searchLink>; Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.; The Key Laboratory of Assisted Circulation, Ministry of Health, Guangzhou, P.R. China.; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, P.R. China.; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, P.R. China.
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        Value: 10.1097/FJC.0000000000000611
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        Text: English
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      – TitleFull: Simvastatin Treatment Protects Myocardium in Noncoronary Artery Cardiac Surgery by Inhibiting Apoptosis Through miR-15a-5p Targeting.
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              Text: 2018 Oct
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