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Senolytics improve physical function and increase lifespan in old age.

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Title: Senolytics improve physical function and increase lifespan in old age.
Authors: Xu M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. mixu@uchc.edu.; University of Connecticut Center on Aging, University of Connecticut Health, Farmington, CT, USA. mixu@uchc.edu., Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Farr JN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Weigand BM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Newcastle University Institute for Ageing and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK., Palmer AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Weivoda MM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Ogrodnik MB; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Newcastle University Institute for Ageing and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK., Hachfeld CM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Fraser DG; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Onken JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Verzosa GC; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Langhi LGP; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Weigl M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Miller JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Jurk D; Newcastle University Institute for Ageing and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK., Singh RJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Allison DB; Department of Epidemiology & Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA.; Nathan Shock Center on Comparative Energetics and Aging, University of Alabama at Birmingham, Birmingham, AL, USA., Ejima K; Department of Epidemiology & Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA.; Nathan Shock Center on Comparative Energetics and Aging, University of Alabama at Birmingham, Birmingham, AL, USA., Hubbard GB; Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ikeno Y; Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA., Cubro H; Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Garovic VD; Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Hou X; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Weroha SJ; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Robbins PD; Department of Molecular Medicine, Center on Aging, Scripps Research Institute, Jupiter, FL, USA., Niedernhofer LJ; Department of Molecular Medicine, Center on Aging, Scripps Research Institute, Jupiter, FL, USA., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. tchkonia.tamar@mayo.edu., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. kirkland.james@mayo.edu.
Source: Nature medicine [Nat Med] 2018 Aug; Vol. 24 (8), pp. 1246-1256. Date of Electronic Publication: 2018 Jul 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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