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Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.

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Title: Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.
Authors: Yogaratnam J; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California., Rito J; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California., Kakuda TN; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California., Fennema H; Janssen Research and Development, Beerse, Belgium., Gupta K; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California., Jekle CA; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California., Mitchell T; Hammersmith Medicines Research, London, United Kingdom., Boyce M; Hammersmith Medicines Research, London, United Kingdom., Sahgal O; Hammersmith Medicines Research, London, United Kingdom., Balaratnam G; hVIVO Services, Queen Mary BioEnterprises Innovation Centre, London, United Kingdom., Chanda S; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California., Van Remoortere P; Janssen Research and Development, Titusville, New Jersey., Symons JA; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California., Fry J; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.
Source: The Journal of infectious diseases [J Infect Dis] 2019 Jan 07; Vol. 219 (2), pp. 177-185.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.
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  Data: <searchLink fieldCode="AU" term="%22Yogaratnam+J%22">Yogaratnam J</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Rito+J%22">Rito J</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Kakuda+TN%22">Kakuda TN</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Fennema+H%22">Fennema H</searchLink>; Janssen Research and Development, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Gupta+K%22">Gupta K</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Jekle+CA%22">Jekle CA</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Mitchell+T%22">Mitchell T</searchLink>; Hammersmith Medicines Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Boyce+M%22">Boyce M</searchLink>; Hammersmith Medicines Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sahgal+O%22">Sahgal O</searchLink>; Hammersmith Medicines Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Balaratnam+G%22">Balaratnam G</searchLink>; hVIVO Services, Queen Mary BioEnterprises Innovation Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chanda+S%22">Chanda S</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Van+Remoortere+P%22">Van Remoortere P</searchLink>; Janssen Research and Development, Titusville, New Jersey.<br /><searchLink fieldCode="AU" term="%22Symons+JA%22">Symons JA</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Fry+J%22">Fry J</searchLink>; Alios Biopharma, part of Janssen Pharmaceutical Companies, South San Francisco, California.
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  Data: <searchLink fieldCode="JN" term="%220413675%22">The Journal of infectious diseases</searchLink> [J Infect Dis] 2019 Jan 07; Vol. 219 (2), pp. 177-185.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0413675 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1537-6613 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221899%22">00221899 </searchLink><i>NLM ISO Abbreviation: </i>J Infect Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1093/infdis/jiy410
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              Text: 2019 Jan 07
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