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Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

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Title: Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
Authors: Young MD; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Mitchell TJ; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK., Vieira Braga FA; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Tran MGB; UCL Division of Surgery and Interventional Science, Royal Free Hospital, London NW3 2PS, UK.; Specialist Centre for Kidney Cancer, Royal Free Hospital, London NW3 2PS, UK., Stewart BJ; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK., Ferdinand JR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK., Collord G; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Botting RA; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Popescu DM; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Loudon KW; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK., Vento-Tormo R; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Stephenson E; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Cagan A; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Farndon SJ; Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.; UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK., Del Castillo Velasco-Herrera M; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Guzzo C; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Richoz N; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK., Mamanova L; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Aho T; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Armitage JN; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK., Riddick ACP; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK., Mushtaq I; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Farrell S; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Rampling D; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK., Nicholson J; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Filby A; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Burge J; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Lisgo S; Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK., Maxwell PH; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Lindsay S; Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK., Warren AY; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Stewart GD; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK., Sebire N; Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.; UCL Great Ormond Street Hospital Institute of Child Health, London WC1N 1E, UK., Coleman N; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK., Haniffa M; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. sb31@sanger.ac.uk mrc38@medschl.cam.ac.uk st9@sanger.ac.uk m.a.haniffa@newcastle.ac.uk.; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK., Teichmann SA; Wellcome Sanger Institute, Hinxton CB10 1SA, UK. sb31@sanger.ac.uk mrc38@medschl.cam.ac.uk st9@sanger.ac.uk m.a.haniffa@newcastle.ac.uk., Clatworthy M; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK. sb31@sanger.ac.uk mrc38@medschl.cam.ac.uk st9@sanger.ac.uk m.a.haniffa@newcastle.ac.uk.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK., Behjati S; Wellcome Sanger Institute, Hinxton CB10 1SA, UK. sb31@sanger.ac.uk mrc38@medschl.cam.ac.uk st9@sanger.ac.uk m.a.haniffa@newcastle.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
Source: Science (New York, N.Y.) [Science] 2018 Aug 10; Vol. 361 (6402), pp. 594-599.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1095-9203
DOI:10.1126/science.aat1699