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Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.

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Title: Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Authors: Kozono S; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Lin YM; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Seo HS; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA., Pinch B; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA., Lian X; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350108, China.; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian, 350108, China., Qiu C; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Herbert MK; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Chen CH; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Tan L; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA., Gao ZJ; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Massefski W; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA., Doctor ZM; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA., Jackson BP; Trace Element Analysis Lab, Dartmouth College, Hanover, NH, 03755, USA., Chen Y; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian, 350108, China., Dhe-Paganon S; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA., Lu KP; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. klu@bidmc.harvard.edu.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. klu@bidmc.harvard.edu.; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian, 350108, China. klu@bidmc.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. klu@bidmc.harvard.edu., Zhou XZ; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. xzhou@bidmc.harvard.edu.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. xzhou@bidmc.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. xzhou@bidmc.harvard.edu.
Source: Nature communications [Nat Commun] 2018 Aug 09; Vol. 9 (1), pp. 3069. Date of Electronic Publication: 2018 Aug 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
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  Data: <searchLink fieldCode="AU" term="%22Kozono+S%22">Kozono S</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Lin+YM%22">Lin YM</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Seo+HS%22">Seo HS</searchLink>; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Pinch+B%22">Pinch B</searchLink>; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.<br /><searchLink fieldCode="AU" term="%22Lian+X%22">Lian X</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350108, China.; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian, 350108, China.<br /><searchLink fieldCode="AU" term="%22Qiu+C%22">Qiu C</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.<br /><searchLink fieldCode="AU" term="%22Herbert+MK%22">Herbert MK</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Gao+ZJ%22">Gao ZJ</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Massefski+W%22">Massefski W</searchLink>; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Doctor+ZM%22">Doctor ZM</searchLink>; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+BP%22">Jackson BP</searchLink>; Trace Element Analysis Lab, Dartmouth College, Hanover, NH, 03755, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian, 350108, China.<br /><searchLink fieldCode="AU" term="%22Dhe-Paganon+S%22">Dhe-Paganon S</searchLink>; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lu+KP%22">Lu KP</searchLink>; Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. klu@bidmc.harvard.edu.; 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