View in EDS

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Saved in:
Bibliographic Details
Title: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
Authors: Bis JC; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA., Jian X; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Kunkle BW; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Chen Y; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Bush WS; Case Western Reserve University, Cleveland Heights, OH, USA., Salerno WJ; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Lancour D; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Ma Y; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Renton AE; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marcora E; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Farrell JJ; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Zhao Y; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Qu L; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ahmad S; Erasmus University Medical Center, Rotterdam, Netherlands., Amin N; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Amouyel P; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Beecham GW; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Below JE; Department of Medical Genetics, Vanderbilt University Medical Center, Nashville, TN, USA., Campion D; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.; Department of Research, Centre Hospitalier du Rouvray, Sotteville-lès-, Rouen, France., Cantwell L; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Charbonnier C; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France., Chung J; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Crane PK; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA., Cruchaga C; Department of Psychiatry, Washington University, St. Louis, MO, USA., Cupples LA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Dartigues JF; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France., Debette S; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.; Department of Neurology and Institute for Neurodegenerative Diseases, Bordeaux University Hospital, Memory Clinic, F-33000, Bordeaux, France., Deleuze JF; Centre National de Recherche en Génomique Humaine, Institut François Jacob, Direction de le Recherche Fondamentale, CEA, Evry, France., Fulton L; McDonnell Genome Institute, Washington University, St. Louis, MO, USA., Gabriel SB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Genin E; Inserm UMR-1078, CHRU Brest, Université Brest, Brest, France., Gibbs RA; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Goate A; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Grenier-Boley B; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Gupta N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haines JL; Case Western Reserve University, Cleveland Heights, OH, USA., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland., Helisalmi S; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Howrigan DP; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ikram MA; Erasmus University Medical Center, Rotterdam, Netherlands., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Konrad J; Department of Psychiatry, Washington University, St. Louis, MO, USA., Kuzma A; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lathrop M; McGill University and Génome Québec Innovation Centre, Montréal, Canada., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Lin H; Department of Medicine (Computational Biomedicine), Boston University School of Medicine, Boston, MA, USA., Mattila K; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Mayeux R; Columbia University, New York, NY, USA., Muzny DM; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Nasser W; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Neale B; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Nho K; Indiana University School of Medicine, Indianapolis, IN, USA., Nicolas G; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France., Patel D; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Perola M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.; University of Tartu, Estonian Genome Center, Tartu, Estonia., Psaty BM; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Quenez O; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France., Rajabli F; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Redon R; Inserm, CNRS, Univ. Nantes, CHU Nantes, l'institut du thorax, Nantes, France., Reitz C; Columbia University, New York, NY, USA., Remes AM; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland.; Unit of Clinical Neuroscience, Neurology, University of Oulu and Medical Research Center, Oulu University Hospital, Oulu, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Sarnowski C; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Schmidt H; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria., Schmidt M; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria., Soininen H; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Thornton TA; Department of Statistics, University of Washington, Seattle, WA, USA., Tosto G; Columbia University, New York, NY, USA., Tzourio C; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France., van der Lee SJ; Erasmus University Medical Center, Rotterdam, Netherlands., van Duijn CM; Erasmus University Medical Center, Rotterdam, Netherlands., Valladares O; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Vardarajan B; Columbia University, New York, NY, USA., Wang LS; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wang W; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wijsman E; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wilson RK; McDonnell Genome Institute, Washington University, St. Louis, MO, USA., Witten D; Department of Statistics, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Worley KC; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Zhang X; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Bellenguez C; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Lambert JC; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Kurki MI; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Daly M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Boerwinkle E; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Lunetta KL; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Destefano AL; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA., Dupuis J; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Martin ER; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA., Schellenberg GD; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Seshadri S; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Naj AC; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Farrer LA; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA. farrer@bu.Edu.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. farrer@bu.Edu.; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.
Corporate Authors: Alzheimer’s Disease Sequencing Project
Source: Molecular psychiatry [Mol Psychiatry] 2020 Aug; Vol. 25 (8), pp. 1859-1875. Date of Electronic Publication: 2018 Aug 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 30108311
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Jian+X%22">Jian X</searchLink>; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kunkle+BW%22">Kunkle BW</searchLink>; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton-Nelson+KL%22">Hamilton-Nelson KL</searchLink>; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bush+WS%22">Bush WS</searchLink>; Case Western Reserve University, Cleveland Heights, OH, USA.<br /><searchLink fieldCode="AU" term="%22Salerno+WJ%22">Salerno WJ</searchLink>; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lancour+D%22">Lancour D</searchLink>; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Renton+AE%22">Renton AE</searchLink>; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marcora+E%22">Marcora E</searchLink>; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Farrell+JJ%22">Farrell JJ</searchLink>; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Qu+L%22">Qu L</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ahmad+S%22">Ahmad S</searchLink>; Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Amin+N%22">Amin N</searchLink>; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.<br /><searchLink fieldCode="AU" term="%22Amouyel+P%22">Amouyel P</searchLink>; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.<br /><searchLink fieldCode="AU" term="%22Beecham+GW%22">Beecham GW</searchLink>; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Below+JE%22">Below JE</searchLink>; Department of Medical Genetics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Campion+D%22">Campion D</searchLink>; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.; Department of Research, Centre Hospitalier du Rouvray, Sotteville-lès-, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Cantwell+L%22">Cantwell L</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Charbonnier+C%22">Charbonnier C</searchLink>; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Chung+J%22">Chung J</searchLink>; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Crane+PK%22">Crane PK</searchLink>; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Cupples+LA%22">Cupples LA</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dartigues+JF%22">Dartigues JF</searchLink>; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Debette+S%22">Debette S</searchLink>; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.; Department of Neurology and Institute for Neurodegenerative Diseases, Bordeaux University Hospital, Memory Clinic, F-33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Deleuze+JF%22">Deleuze JF</searchLink>; Centre National de Recherche en Génomique Humaine, Institut François Jacob, Direction de le Recherche Fondamentale, CEA, Evry, France.<br /><searchLink fieldCode="AU" term="%22Fulton+L%22">Fulton L</searchLink>; McDonnell Genome Institute, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gabriel+SB%22">Gabriel SB</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Genin+E%22">Genin E</searchLink>; Inserm UMR-1078, CHRU Brest, Université Brest, Brest, France.<br /><searchLink fieldCode="AU" term="%22Gibbs+RA%22">Gibbs RA</searchLink>; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Goate+A%22">Goate A</searchLink>; Department of Neuroscience and Ronald M Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Grenier-Boley+B%22">Grenier-Boley B</searchLink>; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.<br /><searchLink fieldCode="AU" term="%22Gupta+N%22">Gupta N</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haines+JL%22">Haines JL</searchLink>; Case Western Reserve University, Cleveland Heights, OH, USA.<br /><searchLink fieldCode="AU" term="%22Havulinna+AS%22">Havulinna AS</searchLink>; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Helisalmi+S%22">Helisalmi S</searchLink>; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hiltunen+M%22">Hiltunen M</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Howrigan+DP%22">Howrigan DP</searchLink>; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ikram+MA%22">Ikram MA</searchLink>; Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kaprio+J%22">Kaprio J</searchLink>; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Konrad+J%22">Konrad J</searchLink>; Department of Psychiatry, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Kuzma+A%22">Kuzma A</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lander+ES%22">Lander ES</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lathrop+M%22">Lathrop M</searchLink>; McGill University and Génome Québec Innovation Centre, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Lehtimäki+T%22">Lehtimäki T</searchLink>; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Lin+H%22">Lin H</searchLink>; Department of Medicine (Computational Biomedicine), Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mattila+K%22">Mattila K</searchLink>; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Mayeux+R%22">Mayeux R</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Muzny+DM%22">Muzny DM</searchLink>; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nasser+W%22">Nasser W</searchLink>; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Neale+B%22">Neale B</searchLink>; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nho+K%22">Nho K</searchLink>; Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Nicolas+G%22">Nicolas G</searchLink>; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Patel+D%22">Patel D</searchLink>; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pericak-Vance+MA%22">Pericak-Vance MA</searchLink>; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Perola+M%22">Perola M</searchLink>; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.; University of Tartu, Estonian Genome Center, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Department of Medicine (General Internal Medicine), University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Quenez+O%22">Quenez O</searchLink>; Department of Genetics and CNR-MAJ, Normandie Université, UNIROUEN, Inserm U1245 and Rouen University Hospital, F 76000, Normandy Centre for Genomic and Personalized Medicine, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Rajabli+F%22">Rajabli F</searchLink>; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Redon+R%22">Redon R</searchLink>; Inserm, CNRS, Univ. Nantes, CHU Nantes, l'institut du thorax, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Reitz+C%22">Reitz C</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Remes+AM%22">Remes AM</searchLink>; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland.; Unit of Clinical Neuroscience, Neurology, University of Oulu and Medical Research Center, Oulu University Hospital, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Salomaa+V%22">Salomaa V</searchLink>; National Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sarnowski+C%22">Sarnowski C</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+H%22">Schmidt H</searchLink>; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Schmidt+M%22">Schmidt M</searchLink>; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+R%22">Schmidt R</searchLink>; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Soininen+H%22">Soininen H</searchLink>; Institute of Clinical Medicine - Neurology and Department of Neurology, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Thornton+TA%22">Thornton TA</searchLink>; Department of Statistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tosto+G%22">Tosto G</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tzourio+C%22">Tzourio C</searchLink>; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22van+der+Lee+SJ%22">van der Lee SJ</searchLink>; Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Duijn+CM%22">van Duijn CM</searchLink>; Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Valladares+O%22">Valladares O</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vardarajan+B%22">Vardarajan B</searchLink>; Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+LS%22">Wang LS</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wijsman+E%22">Wijsman E</searchLink>; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+RK%22">Wilson RK</searchLink>; McDonnell Genome Institute, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Witten+D%22">Witten D</searchLink>; Department of Statistics, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Worley+KC%22">Worley KC</searchLink>; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bellenguez+C%22">Bellenguez C</searchLink>; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.<br /><searchLink fieldCode="AU" term="%22Lambert+JC%22">Lambert JC</searchLink>; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.<br /><searchLink fieldCode="AU" term="%22Kurki+MI%22">Kurki MI</searchLink>; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Palotie+A%22">Palotie A</searchLink>; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics and Genetic Analysis Platform, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Daly+M%22">Daly M</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lunetta+KL%22">Lunetta KL</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Destefano+AL%22">Destefano AL</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dupuis+J%22">Dupuis J</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Martin+ER%22">Martin ER</searchLink>; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Schellenberg+GD%22">Schellenberg GD</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Seshadri+S%22">Seshadri S</searchLink>; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Naj+AC%22">Naj AC</searchLink>; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Farrer+LA%22">Farrer LA</searchLink>; Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA. farrer@bu.Edu.; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.; Departments of Neurology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. farrer@bu.Edu.; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. farrer@bu.Edu.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22Alzheimer%27s+Disease+Sequencing+Project%22">Alzheimer’s Disease Sequencing Project</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2020 Aug; Vol. 25 (8), pp. 1859-1875. <i>Date of Electronic Publication: </i>2018 Aug 14.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=30108311
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41380-018-0112-7
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1859
    Titles:
      – TitleFull: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bis JC
      – PersonEntity:
          Name:
            NameFull: Jian X
      – PersonEntity:
          Name:
            NameFull: Kunkle BW
      – PersonEntity:
          Name:
            NameFull: Chen Y
      – PersonEntity:
          Name:
            NameFull: Hamilton-Nelson KL
      – PersonEntity:
          Name:
            NameFull: Bush WS
      – PersonEntity:
          Name:
            NameFull: Salerno WJ
      – PersonEntity:
          Name:
            NameFull: Lancour D
      – PersonEntity:
          Name:
            NameFull: Ma Y
      – PersonEntity:
          Name:
            NameFull: Renton AE
      – PersonEntity:
          Name:
            NameFull: Marcora E
      – PersonEntity:
          Name:
            NameFull: Farrell JJ
      – PersonEntity:
          Name:
            NameFull: Zhao Y
      – PersonEntity:
          Name:
            NameFull: Qu L
      – PersonEntity:
          Name:
            NameFull: Ahmad S
      – PersonEntity:
          Name:
            NameFull: Amin N
      – PersonEntity:
          Name:
            NameFull: Amouyel P
      – PersonEntity:
          Name:
            NameFull: Beecham GW
      – PersonEntity:
          Name:
            NameFull: Below JE
      – PersonEntity:
          Name:
            NameFull: Campion D
      – PersonEntity:
          Name:
            NameFull: Cantwell L
      – PersonEntity:
          Name:
            NameFull: Charbonnier C
      – PersonEntity:
          Name:
            NameFull: Chung J
      – PersonEntity:
          Name:
            NameFull: Crane PK
      – PersonEntity:
          Name:
            NameFull: Cruchaga C
      – PersonEntity:
          Name:
            NameFull: Cupples LA
      – PersonEntity:
          Name:
            NameFull: Dartigues JF
      – PersonEntity:
          Name:
            NameFull: Debette S
      – PersonEntity:
          Name:
            NameFull: Deleuze JF
      – PersonEntity:
          Name:
            NameFull: Fulton L
      – PersonEntity:
          Name:
            NameFull: Gabriel SB
      – PersonEntity:
          Name:
            NameFull: Genin E
      – PersonEntity:
          Name:
            NameFull: Gibbs RA
      – PersonEntity:
          Name:
            NameFull: Goate A
      – PersonEntity:
          Name:
            NameFull: Grenier-Boley B
      – PersonEntity:
          Name:
            NameFull: Gupta N
      – PersonEntity:
          Name:
            NameFull: Haines JL
      – PersonEntity:
          Name:
            NameFull: Havulinna AS
      – PersonEntity:
          Name:
            NameFull: Helisalmi S
      – PersonEntity:
          Name:
            NameFull: Hiltunen M
      – PersonEntity:
          Name:
            NameFull: Howrigan DP
      – PersonEntity:
          Name:
            NameFull: Ikram MA
      – PersonEntity:
          Name:
            NameFull: Kaprio J
      – PersonEntity:
          Name:
            NameFull: Konrad J
      – PersonEntity:
          Name:
            NameFull: Kuzma A
      – PersonEntity:
          Name:
            NameFull: Lander ES
      – PersonEntity:
          Name:
            NameFull: Lathrop M
      – PersonEntity:
          Name:
            NameFull: Lehtimäki T
      – PersonEntity:
          Name:
            NameFull: Lin H
      – PersonEntity:
          Name:
            NameFull: Mattila K
      – PersonEntity:
          Name:
            NameFull: Mayeux R
      – PersonEntity:
          Name:
            NameFull: Muzny DM
      – PersonEntity:
          Name:
            NameFull: Nasser W
      – PersonEntity:
          Name:
            NameFull: Neale B
      – PersonEntity:
          Name:
            NameFull: Nho K
      – PersonEntity:
          Name:
            NameFull: Nicolas G
      – PersonEntity:
          Name:
            NameFull: Patel D
      – PersonEntity:
          Name:
            NameFull: Pericak-Vance MA
      – PersonEntity:
          Name:
            NameFull: Perola M
      – PersonEntity:
          Name:
            NameFull: Psaty BM
      – PersonEntity:
          Name:
            NameFull: Quenez O
      – PersonEntity:
          Name:
            NameFull: Rajabli F
      – PersonEntity:
          Name:
            NameFull: Redon R
      – PersonEntity:
          Name:
            NameFull: Reitz C
      – PersonEntity:
          Name:
            NameFull: Remes AM
      – PersonEntity:
          Name:
            NameFull: Salomaa V
      – PersonEntity:
          Name:
            NameFull: Sarnowski C
      – PersonEntity:
          Name:
            NameFull: Schmidt H
      – PersonEntity:
          Name:
            NameFull: Schmidt M
      – PersonEntity:
          Name:
            NameFull: Schmidt R
      – PersonEntity:
          Name:
            NameFull: Soininen H
      – PersonEntity:
          Name:
            NameFull: Thornton TA
      – PersonEntity:
          Name:
            NameFull: Tosto G
      – PersonEntity:
          Name:
            NameFull: Tzourio C
      – PersonEntity:
          Name:
            NameFull: van der Lee SJ
      – PersonEntity:
          Name:
            NameFull: van Duijn CM
      – PersonEntity:
          Name:
            NameFull: Valladares O
      – PersonEntity:
          Name:
            NameFull: Vardarajan B
      – PersonEntity:
          Name:
            NameFull: Wang LS
      – PersonEntity:
          Name:
            NameFull: Wang W
      – PersonEntity:
          Name:
            NameFull: Wijsman E
      – PersonEntity:
          Name:
            NameFull: Wilson RK
      – PersonEntity:
          Name:
            NameFull: Witten D
      – PersonEntity:
          Name:
            NameFull: Worley KC
      – PersonEntity:
          Name:
            NameFull: Zhang X
      – PersonEntity:
          Name:
            NameFull: Bellenguez C
      – PersonEntity:
          Name:
            NameFull: Lambert JC
      – PersonEntity:
          Name:
            NameFull: Kurki MI
      – PersonEntity:
          Name:
            NameFull: Palotie A
      – PersonEntity:
          Name:
            NameFull: Daly M
      – PersonEntity:
          Name:
            NameFull: Boerwinkle E
      – PersonEntity:
          Name:
            NameFull: Lunetta KL
      – PersonEntity:
          Name:
            NameFull: Destefano AL
      – PersonEntity:
          Name:
            NameFull: Dupuis J
      – PersonEntity:
          Name:
            NameFull: Martin ER
      – PersonEntity:
          Name:
            NameFull: Schellenberg GD
      – PersonEntity:
          Name:
            NameFull: Seshadri S
      – PersonEntity:
          Name:
            NameFull: Naj AC
      – PersonEntity:
          Name:
            NameFull: Fornage M
      – PersonEntity:
          Name:
            NameFull: Farrer LA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: 2020 Aug
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-electronic
              Value: 1476-5578
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Molecular psychiatry
              Type: main
ResultId 1