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Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells.

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Title: Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells.
Authors: Chung SY; 1Institute of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, National Yang-Ming University, TAIPEI, Republic of China., Chen YH; 1Institute of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, National Yang-Ming University, TAIPEI, Republic of China., Lin PR; 1Institute of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, National Yang-Ming University, TAIPEI, Republic of China., Chao TC; 2Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, TAIPEI, Republic of China.; Faculty of Medicine, School of Medicine, National Yang-Min University, TAIPEI, Republic of China., Su JC; 4Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, TAIPEI, Republic of China., Shiau CW; 1Institute of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, National Yang-Ming University, TAIPEI, Republic of China., Su Y; 1Institute of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, National Yang-Ming University, TAIPEI, Republic of China.
Source: Cell death discovery [Cell Death Discov] 2018 Aug 13; Vol. 4, pp. 25. Date of Electronic Publication: 2018 Aug 13 (Print Publication: 2018).
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: eCollection Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2058-7716
DOI:10.1038/s41420-018-0084-z