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Heterogeneity and Coexistence of T790M and T790 Wild-Type Resistant Subclones Drive Mixed Response to Third-Generation Epidermal Growth Factor Receptor Inhibitors in Lung Cancer.

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Title: Heterogeneity and Coexistence of T790M and T790 Wild-Type Resistant Subclones Drive Mixed Response to Third-Generation Epidermal Growth Factor Receptor Inhibitors in Lung Cancer.
Authors: Piotrowska Z; Massachusetts General Hospital, Boston., Hazar-Rethinam M; Massachusetts General Hospital, Boston., Rizzo C; Massachusetts General Hospital, Boston., Nadres B; Massachusetts General Hospital, Boston., Van Seventer EE; Massachusetts General Hospital, Boston., Shahzade HA; Massachusetts General Hospital, Boston., Lennes IT; Massachusetts General Hospital, Boston., Iafrate AJ; Massachusetts General Hospital, Boston., Dias-Santagata D; Massachusetts General Hospital, Boston., Leshchiner I; Eli and Edythe L. Broad Institute of MIT and Harvard., Jessop NA; Massachusetts General Hospital, Boston., Hu H; Massachusetts General Hospital, Boston., Digumarthy SR; Massachusetts General Hospital, Boston., Nagy RJ; Guardant Health, Redwood City, CA., Lanman RB; Guardant Health, Redwood City, CA., Moody S; Novartis Institutes for Biomedical Research, Cambridge, MA., Niederst MJ; Novartis Institutes for Biomedical Research, Cambridge, MA., Engelman JA; Novartis Institutes for Biomedical Research, Cambridge, MA., Hata AN; Massachusetts General Hospital, Boston., Corcoran RB; Massachusetts General Hospital, Boston., Sequist LV; Massachusetts General Hospital, Boston.
Source: JCO precision oncology [JCO Precis Oncol] 2018; Vol. 2018. Date of Electronic Publication: 2018 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101705370 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2473-4284 (Print) Linking ISSN: 24734284 NLM ISO Abbreviation: JCO Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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