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Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.

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Title: Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.
Authors: Gregus AM; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States.; School of Neuroscience, Virginia Polytechnic and State University, Blacksburg, VA, United States., Buczynski MW; School of Neuroscience, Virginia Polytechnic and State University, Blacksburg, VA, United States.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States., Dumlao DS; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States., Norris PC; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States., Rai G; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States., Simeonov A; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States., Maloney DJ; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States., Jadhav A; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States., Xu Q; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States., Wei SC; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States., Fitzsimmons BL; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States., Dennis EA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States., Yaksh TL; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
Source: Pain [Pain] 2018 Dec; Vol. 159 (12), pp. 2620-2629.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE
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  Data: Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.
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  Data: <searchLink fieldCode="AU" term="%22Gregus+AM%22">Gregus AM</searchLink>; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States.; School of Neuroscience, Virginia Polytechnic and State University, Blacksburg, VA, United States.<br /><searchLink fieldCode="AU" term="%22Buczynski+MW%22">Buczynski MW</searchLink>; School of Neuroscience, Virginia Polytechnic and State University, Blacksburg, VA, United States.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Dumlao+DS%22">Dumlao DS</searchLink>; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Norris+PC%22">Norris PC</searchLink>; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Rai+G%22">Rai G</searchLink>; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Simeonov+A%22">Simeonov A</searchLink>; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Maloney+DJ%22">Maloney DJ</searchLink>; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Jadhav+A%22">Jadhav A</searchLink>; National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, MD, United States.<br /><searchLink fieldCode="AU" term="%22Xu+Q%22">Xu Q</searchLink>; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Wei+SC%22">Wei SC</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Fitzsimmons+BL%22">Fitzsimmons BL</searchLink>; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Dennis+EA%22">Dennis EA</searchLink>; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Yaksh+TL%22">Yaksh TL</searchLink>; Department of Anesthesiology, University of California, San Diego, La Jolla, CA, United States.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
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