Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc.

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Title: Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc.
Authors: Vincent KL; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America., Moss JA; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Marzinke MA; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Pathology, Johns Hopkins University, Sheikh Zayed Tower, Baltimore, Maryland, United States of America., Hendrix CW; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University, Baltimore, Maryland, United States of America., Anton PA; Center for HIV Prevention Research, Division of Digestive Diseases and UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America., Gunawardana M; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Dawson LN; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America., Olive TJ; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America., Pyles RB; Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, United States of America.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America., Baum MM; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.
Source: PloS one [PLoS One] 2018 Aug 22; Vol. 13 (8), pp. e0201952. Date of Electronic Publication: 2018 Aug 22 (Print Publication: 2018).
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc.
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  Data: <searchLink fieldCode="AU" term="%22Vincent+KL%22">Vincent KL</searchLink>; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Moss+JA%22">Moss JA</searchLink>; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Marzinke+MA%22">Marzinke MA</searchLink>; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Pathology, Johns Hopkins University, Sheikh Zayed Tower, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Hendrix+CW%22">Hendrix CW</searchLink>; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Anton+PA%22">Anton PA</searchLink>; Center for HIV Prevention Research, Division of Digestive Diseases and UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Gunawardana+M%22">Gunawardana M</searchLink>; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Dawson+LN%22">Dawson LN</searchLink>; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Olive+TJ%22">Olive TJ</searchLink>; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Pyles+RB%22">Pyles RB</searchLink>; Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, United States of America.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.<br /><searchLink fieldCode="AU" term="%22Baum+MM%22">Baum MM</searchLink>; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2018 Aug 22; Vol. 13 (8), pp. e0201952. <i>Date of Electronic Publication: </i>2018 Aug 22 (<i>Print Publication: </i>2018).
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  Data: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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