View in EDS HTML Full Text PDF Full Text

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.

Saved in:
Bibliographic Details
Title: Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.
Authors: Kenna JG; Safer Medicines Trust, Kingsbridge, UK., Taskar KS; Mechanistic Safety and Disposition, IVIVT, GlaxoSmithKline, Ware, Hertfordshire, UK., Battista C; DILIsym Services Inc., a Simulations Plus Company, Research Triangle Park, North Carolina, USA., Bourdet DL; Drug Metabolism and Pharmacokinetics, Theravance Biopharma, South San Francisco, California, USA., Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Brouwer KR; ADME-TOX, BioIVT, Durham, North Carolina, USA., Dai D; Clinical Pharmacology, Research and Development Sciences, Agios Pharmaceuticals, Cambridge, Massachusetts, USA., Funk C; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland., Hafey MJ; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc, Kenilworth, New Jersey, USA., Lai Y; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA., Maher J; Safety Assessment, Genentech, South San Francisco, California, USA., Pak YA; Lilly Research Laboratory, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana, USA., Pedersen JM; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Novum, Huddinge, Sweden., Polli JW; Mechanistic Safety and Drug Disposition, GlaxoSmithKline, King of Prussia, Pennsylvania, USA., Rodrigues AD; PDM, Medicine Design, Pfizer Inc., Groton, Connecticut, USA., Watkins PB; Institute for Drug Safety Sciences, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA., Yang K; DILIsym Services Inc., a Simulations Plus Company, Research Triangle Park, North Carolina, USA., Yucha RW; Takeda Pharmaceuticals, Global Drug Metabolism and Pharmacokinetics, Cambridge, Massachusetts, USA.
Corporate Authors: International Transporter Consortium
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2018 Nov; Vol. 104 (5), pp. 916-932.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 30137645
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Kenna+JG%22">Kenna JG</searchLink>; Safer Medicines Trust, Kingsbridge, UK.<br /><searchLink fieldCode="AU" term="%22Taskar+KS%22">Taskar KS</searchLink>; Mechanistic Safety and Disposition, IVIVT, GlaxoSmithKline, Ware, Hertfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Battista+C%22">Battista C</searchLink>; DILIsym Services Inc., a Simulations Plus Company, Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Bourdet+DL%22">Bourdet DL</searchLink>; Drug Metabolism and Pharmacokinetics, Theravance Biopharma, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Brouwer+KLR%22">Brouwer KLR</searchLink>; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Brouwer+KR%22">Brouwer KR</searchLink>; ADME-TOX, BioIVT, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Dai+D%22">Dai D</searchLink>; Clinical Pharmacology, Research and Development Sciences, Agios Pharmaceuticals, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Funk+C%22">Funk C</searchLink>; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hafey+MJ%22">Hafey MJ</searchLink>; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc, Kenilworth, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA.<br /><searchLink fieldCode="AU" term="%22Maher+J%22">Maher J</searchLink>; Safety Assessment, Genentech, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Pak+YA%22">Pak YA</searchLink>; Lilly Research Laboratory, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Pedersen+JM%22">Pedersen JM</searchLink>; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Novum, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Polli+JW%22">Polli JW</searchLink>; Mechanistic Safety and Drug Disposition, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Rodrigues+AD%22">Rodrigues AD</searchLink>; PDM, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Watkins+PB%22">Watkins PB</searchLink>; Institute for Drug Safety Sciences, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; DILIsym Services Inc., a Simulations Plus Company, Research Triangle Park, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Yucha+RW%22">Yucha RW</searchLink>; Takeda Pharmaceuticals, Global Drug Metabolism and Pharmacokinetics, Cambridge, Massachusetts, USA.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22International+Transporter+Consortium%22">International Transporter Consortium</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220372741%22">Clinical pharmacology and therapeutics</searchLink> [Clin Pharmacol Ther] 2018 Nov; Vol. 104 (5), pp. 916-932.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural; Review
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372741 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-6535 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099236%22">00099236 </searchLink><i>NLM ISO Abbreviation: </i>Clin Pharmacol Ther <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=30137645
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/cpt.1222
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 916
    Titles:
      – TitleFull: Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kenna JG
      – PersonEntity:
          Name:
            NameFull: Taskar KS
      – PersonEntity:
          Name:
            NameFull: Battista C
      – PersonEntity:
          Name:
            NameFull: Bourdet DL
      – PersonEntity:
          Name:
            NameFull: Brouwer KLR
      – PersonEntity:
          Name:
            NameFull: Brouwer KR
      – PersonEntity:
          Name:
            NameFull: Dai D
      – PersonEntity:
          Name:
            NameFull: Funk C
      – PersonEntity:
          Name:
            NameFull: Hafey MJ
      – PersonEntity:
          Name:
            NameFull: Lai Y
      – PersonEntity:
          Name:
            NameFull: Maher J
      – PersonEntity:
          Name:
            NameFull: Pak YA
      – PersonEntity:
          Name:
            NameFull: Pedersen JM
      – PersonEntity:
          Name:
            NameFull: Polli JW
      – PersonEntity:
          Name:
            NameFull: Rodrigues AD
      – PersonEntity:
          Name:
            NameFull: Watkins PB
      – PersonEntity:
          Name:
            NameFull: Yang K
      – PersonEntity:
          Name:
            NameFull: Yucha RW
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: 2018 Nov
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-electronic
              Value: 1532-6535
          Numbering:
            – Type: volume
              Value: 104
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Clinical pharmacology and therapeutics
              Type: main
ResultId 1