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The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

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Title: The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.
Authors: D'Cruz AA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Speir M; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Bliss-Moreau M; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Dietrich S; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Wang S; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Chen AA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Gavillet M; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Department of Hematology, Lausanne University Hospital, 1011 Lausanne, Switzerland., Al-Obeidi A; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Lawlor KE; Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3052, Australia., Vince JE; Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3052, Australia., Kelliher MA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA., Hakem R; Ontario Cancer Institute, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada., Pasparakis M; Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany., Williams DA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Ericsson M; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Croker BA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA. ben.croker@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Source: Science signaling [Sci Signal] 2018 Sep 04; Vol. 11 (546). Date of Electronic Publication: 2018 Sep 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.
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  Data: <searchLink fieldCode="AU" term="%22D'Cruz+AA%22">D'Cruz AA</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Speir+M%22">Speir M</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Bliss-Moreau+M%22">Bliss-Moreau M</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Dietrich+S%22">Dietrich S</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Chen+AA%22">Chen AA</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Gavillet+M%22">Gavillet M</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Department of Hematology, Lausanne University Hospital, 1011 Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Al-Obeidi+A%22">Al-Obeidi A</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lawlor+KE%22">Lawlor KE</searchLink>; Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Vince+JE%22">Vince JE</searchLink>; Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Kelliher+MA%22">Kelliher MA</searchLink>; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Hakem+R%22">Hakem R</searchLink>; Ontario Cancer Institute, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Pasparakis+M%22">Pasparakis M</searchLink>; Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Williams+DA%22">Williams DA</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Ericsson+M%22">Ericsson M</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Croker+BA%22">Croker BA</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA. ben.croker@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2018 Sep 04; Vol. 11 (546). <i>Date of Electronic Publication: </i>2018 Sep 04.
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