Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.

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Title: Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.
Authors: Kokkonda S; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., El Mazouni F; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., White J; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Rowland P; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Manjalanagara K; Syngene International Ltd, Bangalore 560 099, India., Joseph JT; Syngene International Ltd, Bangalore 560 099, India., Garcia-Pérez A; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Fernandez J; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Gamo FJ; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Waterson D; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland., Palmer MJ; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Rathod PK; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States.
Source: ACS omega [ACS Omega] 2018 Aug 31; Vol. 3 (8), pp. 9227-9240. Date of Electronic Publication: 2018 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2470-1343 (Print) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2470-1343
DOI:10.1021/acsomega.8b01573