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Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.

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Title: Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.
Authors: Kokkonda S; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., El Mazouni F; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., White J; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Rowland P; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Manjalanagara K; Syngene International Ltd, Bangalore 560 099, India., Joseph JT; Syngene International Ltd, Bangalore 560 099, India., Garcia-Pérez A; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Fernandez J; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Gamo FJ; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain., Waterson D; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland., Palmer MJ; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Rathod PK; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States.
Source: ACS omega [ACS Omega] 2018 Aug 31; Vol. 3 (8), pp. 9227-9240. Date of Electronic Publication: 2018 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2470-1343 (Print) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
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  Data: Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.
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  Data: <searchLink fieldCode="AU" term="%22Kokkonda+S%22">Kokkonda S</searchLink>; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States.<br /><searchLink fieldCode="AU" term="%22El+Mazouni+F%22">El Mazouni F</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States.<br /><searchLink fieldCode="AU" term="%22White+KL%22">White KL</searchLink>; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22White+J%22">White J</searchLink>; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States.<br /><searchLink fieldCode="AU" term="%22Shackleford+DM%22">Shackleford DM</searchLink>; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Lafuente-Monasterio+MJ%22">Lafuente-Monasterio MJ</searchLink>; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Rowland+P%22">Rowland P</searchLink>; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Manjalanagara+K%22">Manjalanagara K</searchLink>; Syngene International Ltd, Bangalore 560 099, India.<br /><searchLink fieldCode="AU" term="%22Joseph+JT%22">Joseph JT</searchLink>; Syngene International Ltd, Bangalore 560 099, India.<br /><searchLink fieldCode="AU" term="%22Garcia-Pérez+A%22">Garcia-Pérez A</searchLink>; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez+J%22">Fernandez J</searchLink>; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Gamo+FJ%22">Gamo FJ</searchLink>; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.<br /><searchLink fieldCode="AU" term="%22Waterson+D%22">Waterson D</searchLink>; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Burrows+JN%22">Burrows JN</searchLink>; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Palmer+MJ%22">Palmer MJ</searchLink>; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Charman+SA%22">Charman SA</searchLink>; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Rathod+PK%22">Rathod PK</searchLink>; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States.<br /><searchLink fieldCode="AU" term="%22Phillips+MA%22">Phillips MA</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States.
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  Data: <searchLink fieldCode="JN" term="%22101691658%22">ACS omega</searchLink> [ACS Omega] 2018 Aug 31; Vol. 3 (8), pp. 9227-9240. <i>Date of Electronic Publication: </i>2018 Aug 15.
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