Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival.

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Title: Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival.
Authors: Gast CE; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Silk AD; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Zarour L; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA., Riegler L; Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Burkhart JG; Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA., Gustafson KT; Center for Early Detection Advanced Research, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Parappilly MS; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Roh-Johnson M; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA., Goodman JR; Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239, USA., Olson B; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Schmidt M; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Swain JR; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Davies PS; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Shasthri V; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Iizuka S; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Flynn P; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Watson S; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Korkola J; Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Courtneidge SA; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Fischer JM; Center for Early Detection Advanced Research, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA., Jaboin J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Radiation Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Billingsley KG; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Lopez CD; Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Burchard J; Department of Computational Biology, Oregon Health & Science University, Portland, OR 97239, USA., Gray J; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Coussens LM; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Sheppard BC; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Wong MH; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Source: Science advances [Sci Adv] 2018 Sep 12; Vol. 4 (9), pp. eaat7828. Date of Electronic Publication: 2018 Sep 12 (Print Publication: 2018).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: eCollection Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.aat7828