Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
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| Title: | Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis. |
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| Authors: | Hughes CD; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Choi ML; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Ryten M; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK., Hopkins L; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Drews A; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; German Center for Neurodegenerative Diseases, Sigmund-Freud-Straße 27, 53127, Bonn, Germany., Botía JA; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK.; Departamento de Ingeniería de la Información y las Comunicaciones, Universidad de Murcia, 30100, Murcia, Spain., Iljina M; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; Weizmann Institute of Science, Perlman Chemical Sciences Building, Room 601, 76100, Rehovot, Israel., Rodrigues M; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Gagliano SA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gandhi S; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. sonia.gandhi@ucl.ac.uk.; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK. sonia.gandhi@ucl.ac.uk., Bryant C; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK. ceb27@cam.ac.uk., Klenerman D; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. dk10012@cam.ac.uk.; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK. dk10012@cam.ac.uk. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2019 Jan; Vol. 137 (1), pp. 103-120. Date of Electronic Publication: 2018 Sep 17. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 30225556 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hughes+CD%22">Hughes CD</searchLink>; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.<br /><searchLink fieldCode="AU" term="%22Choi+ML%22">Choi ML</searchLink>; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Ryten+M%22">Ryten M</searchLink>; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK.<br /><searchLink fieldCode="AU" term="%22Hopkins+L%22">Hopkins L</searchLink>; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.<br /><searchLink fieldCode="AU" term="%22Drews+A%22">Drews A</searchLink>; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; German Center for Neurodegenerative Diseases, Sigmund-Freud-Straße 27, 53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Botía+JA%22">Botía JA</searchLink>; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK.; Departamento de Ingeniería de la Información y las Comunicaciones, Universidad de Murcia, 30100, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Iljina+M%22">Iljina M</searchLink>; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; Weizmann Institute of Science, Perlman Chemical Sciences Building, Room 601, 76100, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Rodrigues+M%22">Rodrigues M</searchLink>; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.<br /><searchLink fieldCode="AU" term="%22Gagliano+SA%22">Gagliano SA</searchLink>; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gandhi+S%22">Gandhi S</searchLink>; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. sonia.gandhi@ucl.ac.uk.; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK. sonia.gandhi@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Bryant+C%22">Bryant C</searchLink>; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK. ceb27@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Klenerman+D%22">Klenerman D</searchLink>; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. dk10012@cam.ac.uk.; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK. dk10012@cam.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2019 Jan; Vol. 137 (1), pp. 103-120. <i>Date of Electronic Publication: </i>2018 Sep 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0412041 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0533 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200016322%22">00016322 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=30225556 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00401-018-1907-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 103 Titles: – TitleFull: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hughes CD – PersonEntity: Name: NameFull: Choi ML – PersonEntity: Name: NameFull: Ryten M – PersonEntity: Name: NameFull: Hopkins L – PersonEntity: Name: NameFull: Drews A – PersonEntity: Name: NameFull: Botía JA – PersonEntity: Name: NameFull: Iljina M – PersonEntity: Name: NameFull: Rodrigues M – PersonEntity: Name: NameFull: Gagliano SA – PersonEntity: Name: NameFull: Gandhi S – PersonEntity: Name: NameFull: Bryant C – PersonEntity: Name: NameFull: Klenerman D IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2019 Jan Type: published Y: 2019 Identifiers: – Type: issn-electronic Value: 1432-0533 Numbering: – Type: volume Value: 137 – Type: issue Value: 1 Titles: – TitleFull: Acta neuropathologica Type: main |
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