Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
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| Title: | Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis. |
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| Authors: | Hughes CD; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Choi ML; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Ryten M; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK., Hopkins L; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK., Drews A; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; German Center for Neurodegenerative Diseases, Sigmund-Freud-Straße 27, 53127, Bonn, Germany., Botía JA; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK.; Departamento de Ingeniería de la Información y las Comunicaciones, Universidad de Murcia, 30100, Murcia, Spain., Iljina M; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.; Weizmann Institute of Science, Perlman Chemical Sciences Building, Room 601, 76100, Rehovot, Israel., Rodrigues M; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Gagliano SA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gandhi S; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. sonia.gandhi@ucl.ac.uk.; Department of Molecular Neuroscience, University College London Institute of Neurology, London, WC1N 3BG, UK. sonia.gandhi@ucl.ac.uk., Bryant C; Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK. ceb27@cam.ac.uk., Klenerman D; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. dk10012@cam.ac.uk.; UK Dementia Research Institute, University of Cambridge, Cambridge, CB2 0XY, UK. dk10012@cam.ac.uk. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2019 Jan; Vol. 137 (1), pp. 103-120. Date of Electronic Publication: 2018 Sep 17. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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