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Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.

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Title: Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.
Authors: Molinari A; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy., Fallacara AL; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy., Di Maria S; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy., Zamperini C; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy., Poggialini F; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy., Musumeci F; Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV 3, Genoa 16132, Italy., Schenone S; Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV 3, Genoa 16132, Italy., Angelucci A; Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università dell'Aquila, Via Vetoio, 67100 Coppito, L'Aquila, Italy., Colapietro A; Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università dell'Aquila, Via Vetoio, 67100 Coppito, L'Aquila, Italy., Crespan E; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy., Kissova M; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy., Maga G; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy., Botta M; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology Temple University, BioLife Science Building, Suite 333, 1900 North 12th Street, Philadelphia, PA 19122, United States; Lead Discovery Siena S.r.l., Via Vittorio Alfieri 31, 53019 Castelnuovo Berardenga, Siena, Italy. Electronic address: botta.maurizio@gmail.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Nov 15; Vol. 28 (21), pp. 3454-3457. Date of Electronic Publication: 2018 Sep 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.
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  Data: <searchLink fieldCode="AU" term="%22Molinari+A%22">Molinari A</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Fallacara+AL%22">Fallacara AL</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Maria+S%22">Di Maria S</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Zamperini+C%22">Zamperini C</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Poggialini+F%22">Poggialini F</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Musumeci+F%22">Musumeci F</searchLink>; Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV 3, Genoa 16132, Italy.<br /><searchLink fieldCode="AU" term="%22Schenone+S%22">Schenone S</searchLink>; Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV 3, Genoa 16132, Italy.<br /><searchLink fieldCode="AU" term="%22Angelucci+A%22">Angelucci A</searchLink>; Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università dell'Aquila, Via Vetoio, 67100 Coppito, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Colapietro+A%22">Colapietro A</searchLink>; Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università dell'Aquila, Via Vetoio, 67100 Coppito, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Crespan+E%22">Crespan E</searchLink>; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Kissova+M%22">Kissova M</searchLink>; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Maga+G%22">Maga G</searchLink>; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Botta+M%22">Botta M</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology Temple University, BioLife Science Building, Suite 333, 1900 North 12th Street, Philadelphia, PA 19122, United States; Lead Discovery Siena S.r.l., Via Vittorio Alfieri 31, 53019 Castelnuovo Berardenga, Siena, Italy. Electronic address: botta.maurizio@gmail.com.
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