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Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial.

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Title: Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial.
Authors: Vincent KL; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America., Moss JA; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Marzinke MA; Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America., Hendrix CW; Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America., Anton PA; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.; Center for HIV Prevention Research, Division of Digestive Diseases and UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America., Pyles RB; Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, United States of America.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America., Guthrie KM; The Centers for Behavioral & Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, United States of America.; Department of Psychiatry & Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Dawson L; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America., Olive TJ; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, United States of America., Butkyavichene I; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Churchman SA; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Cortez JM Jr; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Fanter R; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Gunawardana M; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Miller CS; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Yang F; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America., Rosen RK; The Centers for Behavioral & Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, United States of America.; Department of Behavioral & Social Sciences, Brown University School of Public Health, Providence, Rhode Island, United States of America., Vargas SE; The Centers for Behavioral & Preventive Medicine, The Miriam Hospital, Providence, Rhode Island, United States of America.; Department of Psychiatry & Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Baum MM; Department of Chemistry, Oak Crest Institute of Science, Monrovia, California, United States of America.
Source: PLoS medicine [PLoS Med] 2018 Sep 28; Vol. 15 (9), pp. e1002655. Date of Electronic Publication: 2018 Sep 28 (Print Publication: 2018).
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101231360 Publication Model: eCollection Cited Medium: Internet ISSN: 1549-1676 (Electronic) Linking ISSN: 15491277 NLM ISO Abbreviation: PLoS Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial.
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