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Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.

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Title: Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.
Authors: Kondrashova O; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia., Topp M; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medicine and Health Sciences, Monash University, Clayton, VIC, 3168, Australia., Nesic K; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia., Lieschke E; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia., Ho GY; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia.; Royal Women's Hospital, Parkville, VIC, 3052, Australia.; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia., Harrell MI; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, 98195, USA., Zapparoli GV; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, 3086, Australia., Hadley A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia., Holian R; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; School of Medicine, University of Melbourne, Parkville, VIC, 3052, Australia., Boehm E; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; School of Medicine, University of Melbourne, Parkville, VIC, 3052, Australia., Heong V; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia.; Royal Women's Hospital, Parkville, VIC, 3052, Australia., Sanij E; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, 3010, Australia., Pearson RB; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, 3010, Australia.; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC, 3010, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3168, Australia., Krais JJ; Fox Chase Cancer Centre, Philadelphia, PA, 19111, USA., Johnson N; Fox Chase Cancer Centre, Philadelphia, PA, 19111, USA., McNally O; Royal Women's Hospital, Parkville, VIC, 3052, Australia., Ananda S; Royal Women's Hospital, Parkville, VIC, 3052, Australia., Alsop K; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia., Hutt KJ; Department of Medicine and Health Sciences, Monash University, Clayton, VIC, 3168, Australia., Kaufmann SH; Departments of Oncology and Molecular Pharmacology, Mayo Clinic, Rochester, MN, 55905, USA., Lin KK; Clovis Oncology, Boulder, CO, 80301, USA., Harding TC; Clovis Oncology, Boulder, CO, 80301, USA., Traficante N; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, 3010, Australia., deFazio A; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney Medical School, The University of Sydney and Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, 2145, Australia., McNeish IA; Division of Cancer, Department of Surgery and Cancer, Imperial College London, Kensington, London, SW7 2AZ, United Kingdom., Bowtell DD; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, 3010, Australia., Swisher EM; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, 98195, USA., Dobrovic A; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, 3086, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, 3010, Australia., Wakefield MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Melbourne Bioinformatics, University of Melbourne, Melbourne, VIC, 3010, Australia., Scott CL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. scottc@wehi.edu.au.; Department of Medicine and Health Sciences, Monash University, Clayton, VIC, 3168, Australia. scottc@wehi.edu.au.; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia. scottc@wehi.edu.au.
Corporate Authors: Australian Ovarian Cancer Study (AOCS)
Source: Nature communications [Nat Commun] 2018 Sep 28; Vol. 9 (1), pp. 3970. Date of Electronic Publication: 2018 Sep 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.
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The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia.; Royal Women's Hospital, Parkville, VIC, 3052, Australia.; Research Division, Peter MacCallum Cancer Centre, Grattan Street, Parkville, VIC, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Harrell+MI%22">Harrell MI</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Zapparoli+GV%22">Zapparoli GV</searchLink>; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.; School of Cancer Medicine, La Trobe University, Bundoora, VIC, 3086, Australia.<br /><searchLink fieldCode="AU" term="%22Hadley+A%22">Hadley A</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Holian+R%22">Holian R</searchLink>; 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