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Fisetin is a senotherapeutic that extends health and lifespan.

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Title: Fisetin is a senotherapeutic that extends health and lifespan.
Authors: Yousefzadeh MJ; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States., McGowan SJ; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Angelini L; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Fuhrmann-Stroissnigg H; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Xu M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States., Ling YY; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Melos KI; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States., Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States., McGuckian C; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Wade EA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Kato JI; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Grassi D; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States., Wentworth M; Office of Research Regulatory Support, Mayo Clinic, Rochester, MN 55905, United States., Burd CE; Department of Molecular Genetics and Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, United States., Arriaga EA; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455-0431, United States., Ladiges WL; Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States., Robbins PD; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States. Electronic address: probbins@umn.edu., Niedernhofer LJ; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States. Electronic address: lniedernh@umn.edu.
Source: EBioMedicine [EBioMedicine] 2018 Oct; Vol. 36, pp. 18-28. Date of Electronic Publication: 2018 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yousefzadeh+MJ%22">Yousefzadeh MJ</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States.<br /><searchLink fieldCode="AU" term="%22McGowan+SJ%22">McGowan SJ</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Angelini+L%22">Angelini L</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Fuhrmann-Stroissnigg+H%22">Fuhrmann-Stroissnigg H</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States.<br /><searchLink fieldCode="AU" term="%22Ling+YY%22">Ling YY</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Melos+KI%22">Melos KI</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Pirtskhalava+T%22">Pirtskhalava T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States.<br /><searchLink fieldCode="AU" term="%22Inman+CL%22">Inman CL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States.<br /><searchLink fieldCode="AU" term="%22McGuckian+C%22">McGuckian C</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Wade+EA%22">Wade EA</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Kato+JI%22">Kato JI</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Grassi+D%22">Grassi D</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.<br /><searchLink fieldCode="AU" term="%22Wentworth+M%22">Wentworth M</searchLink>; Office of Research Regulatory Support, Mayo Clinic, Rochester, MN 55905, United States.<br /><searchLink fieldCode="AU" term="%22Burd+CE%22">Burd CE</searchLink>; Department of Molecular Genetics and Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, United States.<br /><searchLink fieldCode="AU" term="%22Arriaga+EA%22">Arriaga EA</searchLink>; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455-0431, United States.<br /><searchLink fieldCode="AU" term="%22Ladiges+WL%22">Ladiges WL</searchLink>; Department of Comparative Medicine, University of Washington, Seattle, WA 98195, United States.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, United States.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States. Electronic address: probbins@umn.edu.<br /><searchLink fieldCode="AU" term="%22Niedernhofer+LJ%22">Niedernhofer LJ</searchLink>; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States. Electronic address: lniedernh@umn.edu.
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