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Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer.

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Title: Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer.
Authors: Zhang Y; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Kirane A; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.; Division of Surgical Oncology, Department of Surgery, UC Davis Medical Center, Sacramento, California., Huang H; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Sorrelle NB; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Burrows FJ; Kura Oncology, Inc., La Jolla, California., Dellinger MT; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Brekken RA; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. rolf.brekken@utsouthwestern.edu.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.
Source: Molecular cancer research : MCR [Mol Cancer Res] 2019 Feb; Vol. 17 (2), pp. 348-355. Date of Electronic Publication: 2018 Oct 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.<br /><searchLink fieldCode="AU" term="%22Kirane+A%22">Kirane A</searchLink>; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.; Division of Surgical Oncology, Department of Surgery, UC Davis Medical Center, Sacramento, California.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.<br /><searchLink fieldCode="AU" term="%22Sorrelle+NB%22">Sorrelle NB</searchLink>; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.<br /><searchLink fieldCode="AU" term="%22Burrows+FJ%22">Burrows FJ</searchLink>; Kura Oncology, Inc., La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Dellinger+MT%22">Dellinger MT</searchLink>; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.<br /><searchLink fieldCode="AU" term="%22Brekken+RA%22">Brekken RA</searchLink>; Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. rolf.brekken@utsouthwestern.edu.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101150042 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3125 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215417786%22">15417786 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/1541-7786.MCR-18-0427
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        Text: English
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      – TitleFull: Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer.
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              Text: 2019 Feb
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