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Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

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Title: Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Authors: Dong YY; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Wang H; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Pike ACW; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Cochrane SA; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK; School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK., Hamedzadeh S; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Wyszyński FJ; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Bushell SR; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Royer SF; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Widdick DA; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Sajid A; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Park Y; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Lucas R; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Liu WM; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Lee SS; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Machida T; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Minall L; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK., Mehmood S; Department of Chemistry, Oxford, OX1 3QZ, UK., Belaya K; Neurosciences Group, Nuffield Department of Clinical Neuroscience, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK., Liu WW; Neurosciences Group, Nuffield Department of Clinical Neuroscience, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK., Chu A; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Shrestha L; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Mukhopadhyay SMM; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Strain-Damerell C; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Chalk R; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Burgess-Brown NA; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK., Bibb MJ; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK., Barry Iii CE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., Robinson CV; Department of Chemistry, Oxford, OX1 3QZ, UK., Beeson D; Neurosciences Group, Nuffield Department of Clinical Neuroscience, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK., Davis BG; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. Electronic address: Ben.Davis@chem.ox.ac.uk., Carpenter EP; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK. Electronic address: liz.carpenter@sgc.ox.ac.uk.
Source: Cell [Cell] 2018 Nov 01; Vol. 175 (4), pp. 1045-1058.e16.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell
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  Data: Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
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  Data: <searchLink fieldCode="AU" term="%22Dong+YY%22">Dong YY</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Pike+ACW%22">Pike ACW</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Cochrane+SA%22">Cochrane SA</searchLink>; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK; School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Hamedzadeh+S%22">Hamedzadeh S</searchLink>; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Wyszyński+FJ%22">Wyszyński FJ</searchLink>; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Bushell+SR%22">Bushell SR</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Royer+SF%22">Royer SF</searchLink>; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Widdick+DA%22">Widdick DA</searchLink>; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK.<br /><searchLink fieldCode="AU" term="%22Sajid+A%22">Sajid A</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.<br /><searchLink fieldCode="AU" term="%22Boshoff+HI%22">Boshoff HI</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.<br /><searchLink fieldCode="AU" term="%22Park+Y%22">Park Y</searchLink>; 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Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Chalk+R%22">Chalk R</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Burgess-Brown+NA%22">Burgess-Brown NA</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Bibb+MJ%22">Bibb MJ</searchLink>; Department of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK.<br /><searchLink fieldCode="AU" term="%22Barry+Iii+CE%22">Barry Iii CE</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.<br /><searchLink fieldCode="AU" term="%22Robinson+CV%22">Robinson CV</searchLink>; Department of Chemistry, Oxford, OX1 3QZ, UK.<br /><searchLink fieldCode="AU" term="%22Beeson+D%22">Beeson D</searchLink>; Neurosciences Group, Nuffield Department of Clinical Neuroscience, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.<br /><searchLink fieldCode="AU" term="%22Davis+BG%22">Davis BG</searchLink>; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. 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