Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration.
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| Title: | Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. |
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| Authors: | McFarland JM; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Ho ZV; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Kugener G; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Dempster JM; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Montgomery PG; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Bryan JG; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Krill-Burger JM; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Green TM; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.; Dana-Farber Cancer Institute, Boston, 02215, MA, USA., Boehm JS; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.; Dana-Farber Cancer Institute, Boston, 02215, MA, USA.; Harvard Medical School, Boston, 02115, MA, USA.; Boston Children's Hospital, Boston, 02115, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, 20815, MD, USA., Hahn WC; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA.; Dana-Farber Cancer Institute, Boston, 02215, MA, USA.; Harvard Medical School, Boston, 02115, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, 02115, MA, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA., Tsherniak A; Broad Institute of MIT and Harvard, Cambridge, 02142, MA, USA. aviad@broadinstitute.org. |
| Source: | Nature communications [Nat Commun] 2018 Nov 02; Vol. 9 (1), pp. 4610. Date of Electronic Publication: 2018 Nov 02. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-018-06916-5 |
