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A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.

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Title: A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.
Authors: Compte M; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain., Harwood SL; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark., Muñoz IG; Crystallography and Protein Engineering Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Navarro R; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Zonca M; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain., Perez-Chacon G; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm), CSIC-UAM, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), 28029, Madrid, Spain., Erce-Llamazares A; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain., Merino N; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160, Derio, Spain., Tapia-Galisteo A; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Cuesta AM; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Mikkelsen K; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark., Caleiras E; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Nuñez-Prado N; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Aznar MA; Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain., Lykkemark S; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark., Martínez-Torrecuadrada J; Crystallography and Protein Engineering Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain., Melero I; Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.; Department of Immunology, University Clinic, University of Navarra, 31008 Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain.; CIBERONC-Centro virtual de Investigación Biomédica en red de Oncología, 28029 Madrid, Spain., Blanco FJ; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, 48013, Bilbao, Spain., Bernardino de la Serna J; Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Research Complex at Harwell, OX11 0QX Harwell-Oxford, UK.; Department of Physics, King's College London, WC2R 2LS London, UK., Zapata JM; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm), CSIC-UAM, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), 28029, Madrid, Spain., Sanz L; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain., Alvarez-Vallina L; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark. lav@eng.au.dk.; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain. lav@eng.au.dk.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (i+12), 28041, Madrid, Spain. lav@eng.au.dk.
Source: Nature communications [Nat Commun] 2018 Nov 15; Vol. 9 (1), pp. 4809. Date of Electronic Publication: 2018 Nov 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Compte+M%22">Compte M</searchLink>; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Harwood+SL%22">Harwood SL</searchLink>; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Muñoz+IG%22">Muñoz IG</searchLink>; Crystallography and Protein Engineering Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Navarro+R%22">Navarro R</searchLink>; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zonca+M%22">Zonca M</searchLink>; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Perez-Chacon+G%22">Perez-Chacon G</searchLink>; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm), CSIC-UAM, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Erce-Llamazares+A%22">Erce-Llamazares A</searchLink>; Department of Antibody Engineering, Leadartis SL, 28008, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Merino+N%22">Merino N</searchLink>; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Tapia-Galisteo+A%22">Tapia-Galisteo A</searchLink>; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cuesta+AM%22">Cuesta AM</searchLink>; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Mikkelsen+K%22">Mikkelsen K</searchLink>; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Caleiras+E%22">Caleiras E</searchLink>; Histopathology Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Nuñez-Prado+N%22">Nuñez-Prado N</searchLink>; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Aznar+MA%22">Aznar MA</searchLink>; Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Lykkemark+S%22">Lykkemark S</searchLink>; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Martínez-Torrecuadrada+J%22">Martínez-Torrecuadrada J</searchLink>; Crystallography and Protein Engineering Unit, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Melero+I%22">Melero I</searchLink>; Department of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.; Department of Immunology, University Clinic, University of Navarra, 31008 Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain.; CIBERONC-Centro virtual de Investigación Biomédica en red de Oncología, 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Blanco+FJ%22">Blanco FJ</searchLink>; Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia, 48160, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, 48013, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Bernardino+de+la+Serna+J%22">Bernardino de la Serna J</searchLink>; Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Research Complex at Harwell, OX11 0QX Harwell-Oxford, UK.; Department of Physics, King's College London, WC2R 2LS London, UK.<br /><searchLink fieldCode="AU" term="%22Zapata+JM%22">Zapata JM</searchLink>; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm), CSIC-UAM, 28029, Madrid, Spain.; Instituto de Investigación Sanitaria La Paz (IdiPaz), 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+L%22">Sanz L</searchLink>; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alvarez-Vallina+L%22">Alvarez-Vallina L</searchLink>; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000C, Aarhus, Denmark. lav@eng.au.dk.; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, 28041, Madrid, Spain. lav@eng.au.dk.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (i+12), 28041, Madrid, Spain. lav@eng.au.dk.
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