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Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.

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Title: Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.
Authors: Sahu A; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, 15213, PA, USA.; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, 15261, PA, USA., Mamiya H; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, 15213, PA, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, 15260, PA, USA., Shinde SN; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, 15213, PA, USA., Cheikhi A; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, 15213, PA, USA.; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, 15213, PA, USA., Winter LL; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, 15213, PA, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, 15260, PA, USA., Vo NV; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 15213, PA, USA.; Department of Pathology, University of Pittsburgh, Pittsburgh, 15261, PA, USA., Stolz D; Department of Cell Biology, University of Pittsburgh, Pittsburgh, 15261, PA, USA., Roginskaya V; Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, 15232, PA, USA., Tang WY; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, 21218-2608, MD, USA., St Croix C; Department of Cell Biology, University of Pittsburgh, Pittsburgh, 15261, PA, USA., Sanders LH; Department of Neurology, Duke University School of Medicine, Durham, 27704, NC, USA., Franti M; Research Beyond Borders: Boehringer-Ingelheim Pharmaceuticals, Ridgefield, 06877, CT, USA., Van Houten B; Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, 15232, PA, USA., Rando TA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; The Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Center for Tissue Regeneration, Restoration and Repair, Veterans Affairs Hospital, Palo Alto, CA, 94036, USA., Barchowsky A; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, 15261, PA, USA.; Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, 15232, PA, USA., Ambrosio F; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, 15213, PA, USA. ambrosiof@upmc.edu.; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, 15261, PA, USA. ambrosiof@upmc.edu.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, 15260, PA, USA. ambrosiof@upmc.edu.; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 15213, PA, USA. ambrosiof@upmc.edu.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, 15219, PA, USA. ambrosiof@upmc.edu.
Source: Nature communications [Nat Commun] 2018 Nov 19; Vol. 9 (1), pp. 4859. Date of Electronic Publication: 2018 Nov 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration.
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