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Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.

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Title: Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.
Authors: Elsayed MSA; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States., Nielsen JJ; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States., Park S; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States., Park J; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States., Liu Q; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; Department of Pathology and Mary H. Weiser Food Allergy Center , University of Michigan Medical School , Ann Arbor , Michigan 48109 , United States., Kim CH; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.; Department of Pathology and Mary H. Weiser Food Allergy Center , University of Michigan Medical School , Ann Arbor , Michigan 48109 , United States., Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research , National Cancer Institute , Bethesda , Maryland 20892 , United States., Agama K; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research , National Cancer Institute , Bethesda , Maryland 20892 , United States., Low PS; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.; Department of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States., Cushman M; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.
Source: Journal of medicinal chemistry [J Med Chem] 2018 Dec 13; Vol. 61 (23), pp. 10440-10462. Date of Electronic Publication: 2018 Nov 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.
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  Data: <searchLink fieldCode="AU" term="%22Elsayed+MSA%22">Elsayed MSA</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Nielsen+JJ%22">Nielsen JJ</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; Department of Pathology and Mary H. Weiser Food Allergy Center , University of Michigan Medical School , Ann Arbor , Michigan 48109 , United States.<br /><searchLink fieldCode="AU" term="%22Kim+CH%22">Kim CH</searchLink>; Department of Comparative Pathobiology, College of Veterinary Medicine , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.; Department of Pathology and Mary H. Weiser Food Allergy Center , University of Michigan Medical School , Ann Arbor , Michigan 48109 , United States.<br /><searchLink fieldCode="AU" term="%22Pommier+Y%22">Pommier Y</searchLink>; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research , National Cancer Institute , Bethesda , Maryland 20892 , United States.<br /><searchLink fieldCode="AU" term="%22Agama+K%22">Agama K</searchLink>; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research , National Cancer Institute , Bethesda , Maryland 20892 , United States.<br /><searchLink fieldCode="AU" term="%22Low+PS%22">Low PS</searchLink>; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.; Department of Chemistry , Purdue University , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Cushman+M%22">Cushman M</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.; The Purdue Center for Cancer Research , Purdue University , West Lafayette , Indiana 47907 , United States.
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        Value: 10.1021/acs.jmedchem.8b00510
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              Text: 2018 Dec 13
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