Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia.
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| Title: | Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia. |
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| Authors: | Bariana TK; Department of Haematology, University College London, UK.; The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London NHS Foundation Trust, UK.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK., Labarque V; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium., Heremans J; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium., Thys C; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium., De Reys M; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium., Greene D; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, UK., Jenkins B; NIHR Biomedical Research Centre Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge Biomedical Campus, UK., Grassi L; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, UK., Seyres D; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, UK., Burden F; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK., Whitehorn D; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK., Shamardina O; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK., Papadia S; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK., Gomez K; Department of Haematology, University College London, UK.; The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London NHS Foundation Trust, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK., BioResource N; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK., Van Geet C; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium., Koulman A; NIHR Biomedical Research Centre Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge Biomedical Campus, UK., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Ghevaert C; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Cambridge University Hospitals, Cambridge Biomedical Campus, UK., Frontini M; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Cambridge University Hospitals, Cambridge Biomedical Campus, UK., Turro E; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, UK.; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, UK.; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, UK., Freson K; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, UK kathleen.freson@med.kuleuven.be.; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Belgium. |
| Source: | Haematologica [Haematologica] 2019 May; Vol. 104 (5), pp. 1036-1045. Date of Electronic Publication: 2018 Nov 22. |
| Publication Type: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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