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Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.

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Title: Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.
Authors: Jarrad AM, Ang CW, Debnath A; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States., Hahn HJ; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States., Woods K; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia., Tan L; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia., Sykes ML; Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland 4111 , Australia., Jones AJ; Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland 4111 , Australia., Pelingon R, Butler MS; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia., Avery VM; Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland 4111 , Australia., West NP; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia., Karoli T, Blaskovich MAT; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia., Cooper MA; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia.
Source: Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11349-11371. Date of Electronic Publication: 2018 Dec 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.
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  Data: <searchLink fieldCode="AU" term="%22Jarrad+AM%22">Jarrad AM</searchLink><br /><searchLink fieldCode="AU" term="%22Ang+CW%22">Ang CW</searchLink><br /><searchLink fieldCode="AU" term="%22Debnath+A%22">Debnath A</searchLink>; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States.<br /><searchLink fieldCode="AU" term="%22Hahn+HJ%22">Hahn HJ</searchLink>; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , La Jolla , California 92093 , United States.<br /><searchLink fieldCode="AU" term="%22Woods+K%22">Woods K</searchLink>; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia.<br /><searchLink fieldCode="AU" term="%22Sykes+ML%22">Sykes ML</searchLink>; Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland 4111 , Australia.<br /><searchLink fieldCode="AU" term="%22Jones+AJ%22">Jones AJ</searchLink>; Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland 4111 , Australia.<br /><searchLink fieldCode="AU" term="%22Pelingon+R%22">Pelingon R</searchLink><br /><searchLink fieldCode="AU" term="%22Butler+MS%22">Butler MS</searchLink>; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia.<br /><searchLink fieldCode="AU" term="%22Avery+VM%22">Avery VM</searchLink>; Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland 4111 , Australia.<br /><searchLink fieldCode="AU" term="%22West+NP%22">West NP</searchLink>; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia.<br /><searchLink fieldCode="AU" term="%22Karoli+T%22">Karoli T</searchLink><br /><searchLink fieldCode="AU" term="%22Blaskovich+MAT%22">Blaskovich MAT</searchLink>; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia.<br /><searchLink fieldCode="AU" term="%22Cooper+MA%22">Cooper MA</searchLink>; Australian Infectious Diseases Research Centre , St. Lucia , Queensland 4067 Australia.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11349-11371. <i>Date of Electronic Publication: </i>2018 Dec 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.8b01578
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              Text: 2018 Dec 27
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