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PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors.

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Title: PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors.
Authors: Gebreyohannes YK; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Burton EA; Plexxikon Inc., Berkeley, CA, USA., Wozniak A; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium. agnieszka.wozniak@kuleuven.be.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. agnieszka.wozniak@kuleuven.be., Matusow B; Plexxikon Inc., Berkeley, CA, USA., Habets G; Plexxikon Inc., Berkeley, CA, USA., Wellens J; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Cornillie J; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Lin J; Plexxikon Inc., Berkeley, CA, USA., Nespi M; Plexxikon Inc., Berkeley, CA, USA., Wu G; Plexxikon Inc., Berkeley, CA, USA., Zhang C; Plexxikon Inc., Berkeley, CA, USA., Bollag G; Plexxikon Inc., Berkeley, CA, USA., Debiec-Rychter M; Department of Human Genetics, KU Leuven and University Hospitals, Leuven, Belgium., Sciot R; Department of Pathology, KU Leuven and University Hospitals, Leuven, Belgium., Schöffski P; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Source: Clinical and experimental medicine [Clin Exp Med] 2019 May; Vol. 19 (2), pp. 201-210. Date of Electronic Publication: 2018 Dec 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med
Database: MEDLINE Ultimate
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  Data: PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors.
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  Data: <searchLink fieldCode="AU" term="%22Gebreyohannes+YK%22">Gebreyohannes YK</searchLink>; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Burton+EA%22">Burton EA</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wozniak+A%22">Wozniak A</searchLink>; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium. agnieszka.wozniak@kuleuven.be.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. agnieszka.wozniak@kuleuven.be.<br /><searchLink fieldCode="AU" term="%22Matusow+B%22">Matusow B</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Habets+G%22">Habets G</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wellens+J%22">Wellens J</searchLink>; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Cornillie+J%22">Cornillie J</searchLink>; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nespi+M%22">Nespi M</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+G%22">Wu G</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bollag+G%22">Bollag G</searchLink>; Plexxikon Inc., Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Debiec-Rychter+M%22">Debiec-Rychter M</searchLink>; Department of Human Genetics, KU Leuven and University Hospitals, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sciot+R%22">Sciot R</searchLink>; Department of Pathology, KU Leuven and University Hospitals, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Schöffski+P%22">Schöffski P</searchLink>; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Herestraat 49 Post 815, 3000, Leuven, Belgium.; Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22100973405%22">Clinical and experimental medicine</searchLink> [Clin Exp Med] 2019 May; Vol. 19 (2), pp. 201-210. <i>Date of Electronic Publication: </i>2018 Dec 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag+Italia%22">Springer-Verlag Italia </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>100973405 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1591-9528 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215918890%22">15918890 </searchLink><i>NLM ISO Abbreviation: </i>Clin Exp Med
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