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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

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Title: SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Authors: Tzelepis K; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. kt404@cam.ac.uk.; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK. kt404@cam.ac.uk., De Braekeleer E; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Aspris D; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Karaiskakio Foundation, Nicosia, Cyprus., Barbieri I; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, CB2 0QQ, Cambridge, UK., Vijayabaskar MS; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Liu WH; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany., Gozdecka M; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK., Metzakopian E; UK Dementia Research Institute, University of Cambridge, Hills Rd, Cambridge, CB2 0AH, UK., Toop HD; School of Chemistry, University of New South Wales, Sydney, Australia.; Exonate Ltd, Milton Science Park, Cambridge, UK., Dudek M; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Robson SC; School of Pharmacy and Biomedical Science, University of Portsmouth, White Swan Road, Portsmouth, PO1 2DT, UK., Hermida-Prado F; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Yang YH; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Babaei-Jadidi R; School of Chemistry, University of New South Wales, Sydney, Australia., Garyfallos DA; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Ponstingl H; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Dias JML; Cancer Molecular Diagnosis Laboratory, National Institute for Health Research, Biomedical Research Centre, University of Cambridge, Cambridge, UK., Gallipoli P; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK., Seiler M; H3 Biomedicine Inc., Cambridge, MA, USA., Buonamici S; H3 Biomedicine Inc., Cambridge, MA, USA., Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany., Bannister AJ; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK., Rad R; Institute of Molecular Oncology and Functional Genomics, Department of Medicine II and TranslaTUM Cancer Center, Technical University of Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, & German Cancer Consortium (DKTK), Heidelberg, Germany., Prinjha RK; Epigenetics DPU, Immunoinflammation and Oncology TA Unit, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.; European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.; Stem Cell Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Huntly B; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK., Batson J; Exonate Ltd, Milton Science Park, Cambridge, UK., Morris JC; School of Chemistry, University of New South Wales, Sydney, Australia.; Exonate Ltd, Milton Science Park, Cambridge, UK., Pina C; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK., Bradley A; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, & German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University München, 80337, Munich, Germany., Bates DO; Exonate Ltd, Milton Science Park, Cambridge, UK.; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, NG2 7UH, UK., Yusa K; Stem Cell Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. ky1@sanger.ac.uk., Kouzarides T; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK. t.kouzarides@gurdon.cam.ac.uk., Vassiliou GS; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. gsv20@sanger.ac.uk.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK. gsv20@sanger.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK. gsv20@sanger.ac.uk.
Source: Nature communications [Nat Commun] 2018 Dec 19; Vol. 9 (1), pp. 5378. Date of Electronic Publication: 2018 Dec 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-018-07620-0