View in EDS HTML Full Text PDF Full Text

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Saved in:
Bibliographic Details
Title: SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Authors: Tzelepis K; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. kt404@cam.ac.uk.; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK. kt404@cam.ac.uk., De Braekeleer E; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Aspris D; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Karaiskakio Foundation, Nicosia, Cyprus., Barbieri I; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, CB2 0QQ, Cambridge, UK., Vijayabaskar MS; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Liu WH; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany., Gozdecka M; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK., Metzakopian E; UK Dementia Research Institute, University of Cambridge, Hills Rd, Cambridge, CB2 0AH, UK., Toop HD; School of Chemistry, University of New South Wales, Sydney, Australia.; Exonate Ltd, Milton Science Park, Cambridge, UK., Dudek M; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Robson SC; School of Pharmacy and Biomedical Science, University of Portsmouth, White Swan Road, Portsmouth, PO1 2DT, UK., Hermida-Prado F; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Yang YH; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Babaei-Jadidi R; School of Chemistry, University of New South Wales, Sydney, Australia., Garyfallos DA; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Ponstingl H; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Dias JML; Cancer Molecular Diagnosis Laboratory, National Institute for Health Research, Biomedical Research Centre, University of Cambridge, Cambridge, UK., Gallipoli P; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK., Seiler M; H3 Biomedicine Inc., Cambridge, MA, USA., Buonamici S; H3 Biomedicine Inc., Cambridge, MA, USA., Vick B; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany., Bannister AJ; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK., Rad R; Institute of Molecular Oncology and Functional Genomics, Department of Medicine II and TranslaTUM Cancer Center, Technical University of Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, & German Cancer Consortium (DKTK), Heidelberg, Germany., Prinjha RK; Epigenetics DPU, Immunoinflammation and Oncology TA Unit, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.; European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.; Stem Cell Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Huntly B; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK., Batson J; Exonate Ltd, Milton Science Park, Cambridge, UK., Morris JC; School of Chemistry, University of New South Wales, Sydney, Australia.; Exonate Ltd, Milton Science Park, Cambridge, UK., Pina C; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK., Bradley A; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Jeremias I; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, & German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University München, 80337, Munich, Germany., Bates DO; Exonate Ltd, Milton Science Park, Cambridge, UK.; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, NG2 7UH, UK., Yusa K; Stem Cell Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. ky1@sanger.ac.uk., Kouzarides T; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK. t.kouzarides@gurdon.cam.ac.uk., Vassiliou GS; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. gsv20@sanger.ac.uk.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK. gsv20@sanger.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK. gsv20@sanger.ac.uk.
Source: Nature communications [Nat Commun] 2018 Dec 19; Vol. 9 (1), pp. 5378. Date of Electronic Publication: 2018 Dec 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 30568163
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Tzelepis+K%22">Tzelepis K</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. kt404@cam.ac.uk.; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK. kt404@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22De+Braekeleer+E%22">De Braekeleer E</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Aspris+D%22">Aspris D</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Karaiskakio Foundation, Nicosia, Cyprus.<br /><searchLink fieldCode="AU" term="%22Barbieri+I%22">Barbieri I</searchLink>; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, CB2 0QQ, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vijayabaskar+MS%22">Vijayabaskar MS</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Liu+WH%22">Liu WH</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Metzakopian+E%22">Metzakopian E</searchLink>; UK Dementia Research Institute, University of Cambridge, Hills Rd, Cambridge, CB2 0AH, UK.<br /><searchLink fieldCode="AU" term="%22Toop+HD%22">Toop HD</searchLink>; School of Chemistry, University of New South Wales, Sydney, Australia.; Exonate Ltd, Milton Science Park, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dudek+M%22">Dudek M</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Robson+SC%22">Robson SC</searchLink>; School of Pharmacy and Biomedical Science, University of Portsmouth, White Swan Road, Portsmouth, PO1 2DT, UK.<br /><searchLink fieldCode="AU" term="%22Hermida-Prado+F%22">Hermida-Prado F</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Yang+YH%22">Yang YH</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Babaei-Jadidi+R%22">Babaei-Jadidi R</searchLink>; School of Chemistry, University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Garyfallos+DA%22">Garyfallos DA</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Ponstingl+H%22">Ponstingl H</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Dias+JML%22">Dias JML</searchLink>; Cancer Molecular Diagnosis Laboratory, National Institute for Health Research, Biomedical Research Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gallipoli+P%22">Gallipoli P</searchLink>; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Seiler+M%22">Seiler M</searchLink>; H3 Biomedicine Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Buonamici+S%22">Buonamici S</searchLink>; H3 Biomedicine Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vick+B%22">Vick B</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bannister+AJ%22">Bannister AJ</searchLink>; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK.<br /><searchLink fieldCode="AU" term="%22Rad+R%22">Rad R</searchLink>; Institute of Molecular Oncology and Functional Genomics, Department of Medicine II and TranslaTUM Cancer Center, Technical University of Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, & German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Prinjha+RK%22">Prinjha RK</searchLink>; Epigenetics DPU, Immunoinflammation and Oncology TA Unit, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK.<br /><searchLink fieldCode="AU" term="%22Marioni+JC%22">Marioni JC</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.; European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.; Stem Cell Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Huntly+B%22">Huntly B</searchLink>; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Batson+J%22">Batson J</searchLink>; Exonate Ltd, Milton Science Park, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; School of Chemistry, University of New South Wales, Sydney, Australia.; Exonate Ltd, Milton Science Park, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pina+C%22">Pina C</searchLink>; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.<br /><searchLink fieldCode="AU" term="%22Bradley+A%22">Bradley A</searchLink>; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Jeremias+I%22">Jeremias I</searchLink>; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, & German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University München, 80337, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bates+DO%22">Bates DO</searchLink>; Exonate Ltd, Milton Science Park, Cambridge, UK.; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, NG2 7UH, UK.<br /><searchLink fieldCode="AU" term="%22Yusa+K%22">Yusa K</searchLink>; Stem Cell Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. ky1@sanger.ac.uk.<br /><searchLink fieldCode="AU" term="%22Kouzarides+T%22">Kouzarides T</searchLink>; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK. t.kouzarides@gurdon.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. gsv20@sanger.ac.uk.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK. gsv20@sanger.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK. gsv20@sanger.ac.uk.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2018 Dec 19; Vol. 9 (1), pp. 5378. <i>Date of Electronic Publication: </i>2018 Dec 19.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=30568163
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-018-07620-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 5378
    Titles:
      – TitleFull: SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tzelepis K
      – PersonEntity:
          Name:
            NameFull: De Braekeleer E
      – PersonEntity:
          Name:
            NameFull: Aspris D
      – PersonEntity:
          Name:
            NameFull: Barbieri I
      – PersonEntity:
          Name:
            NameFull: Vijayabaskar MS
      – PersonEntity:
          Name:
            NameFull: Liu WH
      – PersonEntity:
          Name:
            NameFull: Gozdecka M
      – PersonEntity:
          Name:
            NameFull: Metzakopian E
      – PersonEntity:
          Name:
            NameFull: Toop HD
      – PersonEntity:
          Name:
            NameFull: Dudek M
      – PersonEntity:
          Name:
            NameFull: Robson SC
      – PersonEntity:
          Name:
            NameFull: Hermida-Prado F
      – PersonEntity:
          Name:
            NameFull: Yang YH
      – PersonEntity:
          Name:
            NameFull: Babaei-Jadidi R
      – PersonEntity:
          Name:
            NameFull: Garyfallos DA
      – PersonEntity:
          Name:
            NameFull: Ponstingl H
      – PersonEntity:
          Name:
            NameFull: Dias JML
      – PersonEntity:
          Name:
            NameFull: Gallipoli P
      – PersonEntity:
          Name:
            NameFull: Seiler M
      – PersonEntity:
          Name:
            NameFull: Buonamici S
      – PersonEntity:
          Name:
            NameFull: Vick B
      – PersonEntity:
          Name:
            NameFull: Bannister AJ
      – PersonEntity:
          Name:
            NameFull: Rad R
      – PersonEntity:
          Name:
            NameFull: Prinjha RK
      – PersonEntity:
          Name:
            NameFull: Marioni JC
      – PersonEntity:
          Name:
            NameFull: Huntly B
      – PersonEntity:
          Name:
            NameFull: Batson J
      – PersonEntity:
          Name:
            NameFull: Morris JC
      – PersonEntity:
          Name:
            NameFull: Pina C
      – PersonEntity:
          Name:
            NameFull: Bradley A
      – PersonEntity:
          Name:
            NameFull: Jeremias I
      – PersonEntity:
          Name:
            NameFull: Bates DO
      – PersonEntity:
          Name:
            NameFull: Yusa K
      – PersonEntity:
          Name:
            NameFull: Kouzarides T
      – PersonEntity:
          Name:
            NameFull: Vassiliou GS
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 19
              M: 12
              Text: 2018 Dec 19
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 9
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1