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Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant.

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Title: Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant.
Authors: Boisson-Dupuis S; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. stbo603@rockefeller.edu jean-laurent.casanova@rockefeller.edu.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Ramirez-Alejo N; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Li Z; Cytokine Signaling Unit, Pasteur Institute, Paris, France.; INSERM U1221, Paris, France., Patin E; Human Evolutionary Genetics Unit, Pasteur Institute, Paris, France.; CNRS UMR2000, Paris, France.; Center of Bioinformatics, Biostatistics and Integrative Biology, Pasteur Institute, Paris, France., Rao G; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia., Kerner G; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Lim CK; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore., Krementsov DN; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, USA., Hernandez N; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Ma CS; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia., Zhang Q; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Sidra Medicine, Doha, Qatar., Markle J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Martinez-Barricarte R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Payne K; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia., Fisch R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Deswarte C; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Halpern J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Bouaziz M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Mulwa J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Sivanesan D; Department of Biochemistry, University of Montreal, Montreal, Quebec, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada., Lazarov T; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Naves R; Institute of Biochemical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile., Garcia P; Laboratory of Microbiology, Clinical Laboratory Department School of Medicine, Pontifical Catholic University of Chile, Santiago, Chile., Itan Y; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Boisson B; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Checchi A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Jabot-Hanin F; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Guennoun A; Sidra Medicine, Doha, Qatar., Jackson CC; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pekcan S; Department of Pediatric Pulmonology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey., Caliskaner Z; Meram Faculty of Medicine, Department of Internal Medicine, Division of Allergy and Immunology, Necmettin Erbakan University, Konya, Turkey., Inostroza J; Jeffrey Modell Center for Diagnosis and Research in Primary Immunodeficiencies, Faculty of Medicine University of La Frontera, Temuco, Chile., Costa-Carvalho BT; Department of Pediatrics, Federal University of São Paulo Medical School, São Paulo, Brazil., de Albuquerque JAT; Department of Immunology, Institute of Biomedical Sciences, and Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil., Garcia-Ortiz H; National Institute of Genomic Medicine, Mexico City, Mexico., Orozco L; National Institute of Genomic Medicine, Mexico City, Mexico., Ozcelik T; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey., Abid A; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco., Rhorfi IA; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco.; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany., Souhi H; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco., Amrani HN; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco., Zegmout A; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco., Geissmann F; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Michnick SW; Department of Biochemistry, University of Montreal, Montreal, Quebec, Canada., Muller-Fleckenstein I; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany., Fleckenstein B; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany., Puel A; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Ciancanelli MJ; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Marr N; Sidra Medicine, Doha, Qatar., Abolhassani H; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Balcells ME; Department of Infectious Diseases, Medical School, Pontifical Catholic University of Chile, Santiago, Chile., Condino-Neto A; Department of Immunology, Institute of Biomedical Sciences, and Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil., Strickler A; Department of Pediatrics, San Sebastián University, Santiago, Chile., Abarca K; Department of Infectious Diseases and Pediatric Immunology, School of Medicine, Pontifical Catholic University of Chile, Santiago, Chile., Teuscher C; Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT, USA., Ochs HD; Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, WA, USA., Reisli I; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey., Sayar EH; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey., El-Baghdadi J; Genetics Unit, Military Hospital Mohamed V, Hay Riad, Rabat, Morocco., Bustamante J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.; Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris, France., Hammarström L; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore.; Beijing Genomics Institute BGI-Shenzhen, Shenzhen, China., Tangye SG; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia., Pellegrini S; Cytokine Signaling Unit, Pasteur Institute, Paris, France.; INSERM U1221, Paris, France., Quintana-Murci L; Human Evolutionary Genetics Unit, Pasteur Institute, Paris, France.; CNRS UMR2000, Paris, France.; Center of Bioinformatics, Biostatistics and Integrative Biology, Pasteur Institute, Paris, France., Abel L; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. stbo603@rockefeller.edu jean-laurent.casanova@rockefeller.edu.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.; Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.; Howard Hughes Medical Institute, New York, NY, USA.
Source: Science immunology [Sci Immunol] 2018 Dec 21; Vol. 3 (30).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant.
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  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Boisson-Dupuis+S%22">Boisson-Dupuis S</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. stbo603@rockefeller.edu jean-laurent.casanova@rockefeller.edu.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ramirez-Alejo+N%22">Ramirez-Alejo N</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Cytokine Signaling Unit, Pasteur Institute, Paris, France.; INSERM U1221, Paris, France.<br /><searchLink fieldCode="AU" term="%22Patin+E%22">Patin E</searchLink>; Human Evolutionary Genetics Unit, Pasteur Institute, Paris, France.; CNRS UMR2000, Paris, France.; Center of Bioinformatics, Biostatistics and Integrative Biology, Pasteur Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rao+G%22">Rao G</searchLink>; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Kerner+G%22">Kerner G</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Lim+CK%22">Lim CK</searchLink>; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Krementsov+DN%22">Krementsov DN</searchLink>; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+N%22">Hernandez N</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ma+CS%22">Ma CS</searchLink>; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Sidra Medicine, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Markle+J%22">Markle J</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Martinez-Barricarte+R%22">Martinez-Barricarte R</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Payne+K%22">Payne K</searchLink>; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Fisch+R%22">Fisch R</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Deswarte+C%22">Deswarte C</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Halpern+J%22">Halpern J</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bouaziz+M%22">Bouaziz M</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mulwa+J%22">Mulwa J</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sivanesan+D%22">Sivanesan D</searchLink>; Department of Biochemistry, University of Montreal, Montreal, Quebec, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lazarov+T%22">Lazarov T</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Naves+R%22">Naves R</searchLink>; Institute of Biochemical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Garcia+P%22">Garcia P</searchLink>; Laboratory of Microbiology, Clinical Laboratory Department School of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Itan+Y%22">Itan Y</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Boisson+B%22">Boisson B</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Checchi+A%22">Checchi A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jabot-Hanin+F%22">Jabot-Hanin F</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cobat+A%22">Cobat A</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Guennoun+A%22">Guennoun A</searchLink>; Sidra Medicine, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Jackson+CC%22">Jackson CC</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pekcan+S%22">Pekcan S</searchLink>; Department of Pediatric Pulmonology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey.<br /><searchLink fieldCode="AU" term="%22Caliskaner+Z%22">Caliskaner Z</searchLink>; Meram Faculty of Medicine, Department of Internal Medicine, Division of Allergy and Immunology, Necmettin Erbakan University, Konya, Turkey.<br /><searchLink fieldCode="AU" term="%22Inostroza+J%22">Inostroza J</searchLink>; Jeffrey Modell Center for Diagnosis and Research in Primary Immunodeficiencies, Faculty of Medicine University of La Frontera, Temuco, Chile.<br /><searchLink fieldCode="AU" term="%22Costa-Carvalho+BT%22">Costa-Carvalho BT</searchLink>; Department of Pediatrics, Federal University of São Paulo Medical School, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Albuquerque+JAT%22">de Albuquerque JAT</searchLink>; Department of Immunology, Institute of Biomedical Sciences, and Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Garcia-Ortiz+H%22">Garcia-Ortiz H</searchLink>; National Institute of Genomic Medicine, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Orozco+L%22">Orozco L</searchLink>; National Institute of Genomic Medicine, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Ozcelik+T%22">Ozcelik T</searchLink>; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Abid+A%22">Abid A</searchLink>; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco.<br /><searchLink fieldCode="AU" term="%22Rhorfi+IA%22">Rhorfi IA</searchLink>; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco.; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Souhi+H%22">Souhi H</searchLink>; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco.<br /><searchLink fieldCode="AU" term="%22Amrani+HN%22">Amrani HN</searchLink>; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco.<br /><searchLink fieldCode="AU" term="%22Zegmout+A%22">Zegmout A</searchLink>; Department of Pneumology, Military Hospital Mohammed V, Rabat, Morocco.<br /><searchLink fieldCode="AU" term="%22Geissmann+F%22">Geissmann F</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Michnick+SW%22">Michnick SW</searchLink>; Department of Biochemistry, University of Montreal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Muller-Fleckenstein+I%22">Muller-Fleckenstein I</searchLink>; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Fleckenstein+B%22">Fleckenstein B</searchLink>; Institute of Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Puel+A%22">Puel A</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ciancanelli+MJ%22">Ciancanelli MJ</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marr+N%22">Marr N</searchLink>; Sidra Medicine, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Abolhassani+H%22">Abolhassani H</searchLink>; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Balcells+ME%22">Balcells ME</searchLink>; Department of Infectious Diseases, Medical School, Pontifical Catholic University of Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Condino-Neto+A%22">Condino-Neto A</searchLink>; Department of Immunology, Institute of Biomedical Sciences, and Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Strickler+A%22">Strickler A</searchLink>; Department of Pediatrics, San Sebastián University, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Abarca+K%22">Abarca K</searchLink>; Department of Infectious Diseases and Pediatric Immunology, School of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Teuscher+C%22">Teuscher C</searchLink>; Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT, USA.<br /><searchLink fieldCode="AU" term="%22Ochs+HD%22">Ochs HD</searchLink>; Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Reisli+I%22">Reisli I</searchLink>; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey.<br /><searchLink fieldCode="AU" term="%22Sayar+EH%22">Sayar EH</searchLink>; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey.<br /><searchLink fieldCode="AU" term="%22El-Baghdadi+J%22">El-Baghdadi J</searchLink>; Genetics Unit, Military Hospital Mohamed V, Hay Riad, Rabat, Morocco.<br /><searchLink fieldCode="AU" term="%22Bustamante+J%22">Bustamante J</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.; Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hammarström+L%22">Hammarström L</searchLink>; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Clinical Translational Research, Singapore General Hospital, Singapore, Singapore.; Beijing Genomics Institute BGI-Shenzhen, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Tangye+SG%22">Tangye SG</searchLink>; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.; St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Pellegrini+S%22">Pellegrini S</searchLink>; Cytokine Signaling Unit, Pasteur Institute, Paris, France.; INSERM U1221, Paris, France.<br /><searchLink fieldCode="AU" term="%22Quintana-Murci+L%22">Quintana-Murci L</searchLink>; Human Evolutionary Genetics Unit, Pasteur Institute, Paris, France.; CNRS UMR2000, Paris, France.; Center of Bioinformatics, Biostatistics and Integrative Biology, Pasteur Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Abel+L%22">Abel L</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA. stbo603@rockefeller.edu jean-laurent.casanova@rockefeller.edu.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.; Paris Descartes University, Imagine Institute, Paris, France.; Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.; Howard Hughes Medical Institute, New York, NY, USA.
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      – TitleFull: Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant.
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    IsPartOfRelationships:
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          Dates:
            – D: 21
              M: 12
              Text: 2018 Dec 21
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-electronic
              Value: 2470-9468
          Numbering:
            – Type: volume
              Value: 3
            – Type: issue
              Value: 30
          Titles:
            – TitleFull: Science immunology
              Type: main
ResultId 1