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Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

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Title: Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.
Authors: Johnson JA; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Tora G; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Pi Z; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Phillips M; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Yin X; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Yang R; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Zhao L; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Chen AY; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Taylor DS; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Basso M; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Rose A; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Behnia K; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Onorato J; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Chen XQ; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Abell LM; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Lu H; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Locke G; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Caporuscio C; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Galella M; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Adam LP; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Gordon D; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Wexler RR; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Finlay HJ; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Nov 21; Vol. 9 (12), pp. 1263-1268. Date of Electronic Publication: 2018 Nov 21 (Print Publication: 2018).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Johnson+JA%22">Johnson JA</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Tora+G%22">Tora G</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Pi+Z%22">Pi Z</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Phillips+M%22">Phillips M</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Chen+AY%22">Chen AY</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Taylor+DS%22">Taylor DS</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Basso+M%22">Basso M</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Rose+A%22">Rose A</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Behnia+K%22">Behnia K</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Onorato+J%22">Onorato J</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Chen+XQ%22">Chen XQ</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Abell+LM%22">Abell LM</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Locke+G%22">Locke G</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Caporuscio+C%22">Caporuscio C</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Galella+M%22">Galella M</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Adam+LP%22">Adam LP</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Gordon+D%22">Gordon D</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Wexler+RR%22">Wexler RR</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Finlay+HJ%22">Finlay HJ</searchLink>; Departments of Discovery Chemistry, Biology, Pharmaceutics, Mechanistic Biochemistry, Preclinical Candidate Optimization, Bioanalytical Research, and Crystallography, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
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