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Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes Treg development.

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Title: Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes Treg development.
Authors: Aqel SI; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Kraus EE; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Jena N; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Kumari V; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Granitto MC; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA., Mao L; Department of Medicinal Chemistry, University of Florida, Gainsville, FL, USA., Farinas MF; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA., Zhao EY; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Perottino G; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA., Pei W; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Lovett-Racke AE; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Racke MK; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Fuchs JR; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Li C; Department of Medicinal Chemistry, University of Florida, Gainsville, FL, USA., Yang Y; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Source: Clinical and experimental immunology [Clin Exp Immunol] 2019 May; Vol. 196 (2), pp. 215-225. Date of Electronic Publication: 2019 Jan 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2249 (Electronic) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes T<subscript>reg</subscript> development.
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  Data: <searchLink fieldCode="AU" term="%22Aqel+SI%22">Aqel SI</searchLink>; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kraus+EE%22">Kraus EE</searchLink>; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Jena+N%22">Jena N</searchLink>; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kumari+V%22">Kumari V</searchLink>; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Granitto+MC%22">Granitto MC</searchLink>; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mao+L%22">Mao L</searchLink>; Department of Medicinal Chemistry, University of Florida, Gainsville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Farinas+MF%22">Farinas MF</searchLink>; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+EY%22">Zhao EY</searchLink>; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Perottino+G%22">Perottino G</searchLink>; Neuroscience Program, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Pei+W%22">Pei W</searchLink>; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lovett-Racke+AE%22">Lovett-Racke AE</searchLink>; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Racke+MK%22">Racke MK</searchLink>; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Fuchs+JR%22">Fuchs JR</searchLink>; Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Medicinal Chemistry, University of Florida, Gainsville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
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  Data: <searchLink fieldCode="JN" term="%220057202%22">Clinical and experimental immunology</searchLink> [Clin Exp Immunol] 2019 May; Vol. 196 (2), pp. 215-225. <i>Date of Electronic Publication: </i>2019 Jan 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0057202 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2249 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200099104%22">00099104 </searchLink><i>NLM ISO Abbreviation: </i>Clin Exp Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1111/cei.13258
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        Text: English
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              Text: 2019 May
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