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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.

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Title: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.
Authors: Lourenco MV; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Frozza RL; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Oswaldo Cruz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil., de Freitas GB; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Zhang H; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Kincheski GC; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Ribeiro FC; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Gonçalves RA; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Clarke JR; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Beckman D; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Staniszewski A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Berman H; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Guerra LA; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Forny-Germano L; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Meier S; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Wilcock DM; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., de Souza JM; Division of Neurosurgery, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Division of Neurology/Epilepsy Program, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Alves-Leon S; Division of Neurosurgery, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Division of Neurology/Epilepsy Program, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Prado VF; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.; Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada., Prado MAM; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.; Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada., Abisambra JF; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Tovar-Moll F; D'Or Institute for Research and Education , Rio de Janeiro, Brazil.; Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Mattos P; D'Or Institute for Research and Education , Rio de Janeiro, Brazil.; Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Arancio O; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. oa1@cumc.columbia.edu.; Department of Pathology & Cell Biology, Columbia University, New York, NY, USA. oa1@cumc.columbia.edu.; Department of Medicine, Columbia University, New York, NY, USA. oa1@cumc.columbia.edu., Ferreira ST; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ferreira@biof.ufrj.br.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ferreira@biof.ufrj.br., De Felice FG; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. fernanda.defelice@queensu.ca.; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada. fernanda.defelice@queensu.ca.; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada. fernanda.defelice@queensu.ca.
Source: Nature medicine [Nat Med] 2019 Jan; Vol. 25 (1), pp. 165-175. Date of Electronic Publication: 2019 Jan 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.
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  Data: <searchLink fieldCode="AU" term="%22Lourenco+MV%22">Lourenco MV</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Frozza+RL%22">Frozza RL</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Oswaldo Cruz Institute, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Freitas+GB%22">de Freitas GB</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kincheski+GC%22">Kincheski GC</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Ribeiro+FC%22">Ribeiro FC</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+RA%22">Gonçalves RA</searchLink>; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Clarke+JR%22">Clarke JR</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Beckman+D%22">Beckman D</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Staniszewski+A%22">Staniszewski A</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Berman+H%22">Berman H</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Guerra+LA%22">Guerra LA</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Forny-Germano+L%22">Forny-Germano L</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Meier+S%22">Meier S</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Wilcock+DM%22">Wilcock DM</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22de+Souza+JM%22">de Souza JM</searchLink>; Division of Neurosurgery, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Division of Neurology/Epilepsy Program, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves-Leon+S%22">Alves-Leon S</searchLink>; Division of Neurosurgery, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Division of Neurology/Epilepsy Program, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Prado+VF%22">Prado VF</searchLink>; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.; Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Prado+MAM%22">Prado MAM</searchLink>; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.; Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Abisambra+JF%22">Abisambra JF</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Tovar-Moll+F%22">Tovar-Moll F</searchLink>; D'Or Institute for Research and Education , Rio de Janeiro, Brazil.; Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Mattos+P%22">Mattos P</searchLink>; D'Or Institute for Research and Education , Rio de Janeiro, Brazil.; Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Arancio+O%22">Arancio O</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. oa1@cumc.columbia.edu.; Department of Pathology & Cell Biology, Columbia University, New York, NY, USA. oa1@cumc.columbia.edu.; Department of Medicine, Columbia University, New York, NY, USA. oa1@cumc.columbia.edu.<br /><searchLink fieldCode="AU" term="%22Ferreira+ST%22">Ferreira ST</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ferreira@biof.ufrj.br.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ferreira@biof.ufrj.br.<br /><searchLink fieldCode="AU" term="%22De+Felice+FG%22">De Felice FG</searchLink>; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. fernanda.defelice@queensu.ca.; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada. fernanda.defelice@queensu.ca.; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada. fernanda.defelice@queensu.ca.
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