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Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study.

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Title: Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study.
Authors: Hong DS; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: dshong@mdanderson.org., Bauer TM; Medical Oncology, Sarah Cannon Research Institute, Tennessee Oncology, PLLC, Nashville, USA., Lee JJ; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA., Dowlati A; Department of Medicine-Hematology and Oncology, UH Cleveland Medical Center, Cleveland, USA., Brose MS; Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, USA., Farago AF; Department of Medicine, Massachusetts General Hospital, Boston, USA., Taylor M; The Knight Cancer Institute, Oregon Health & Science University, Portland, USA., Shaw AT; Department of Medicine, Massachusetts General Hospital, Boston, USA., Montez S; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA., Meric-Bernstam F; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA., Smith S; Loxo Oncology, South San Francisco, USA., Tuch BB; Loxo Oncology, South San Francisco, USA., Ebata K; Loxo Oncology, South San Francisco, USA., Cruickshank S; Loxo Oncology, South San Francisco, USA., Cox MC; Loxo Oncology, South San Francisco, USA., Burris HA 3rd; Medical Oncology, Sarah Cannon Research Institute, Tennessee Oncology, PLLC, Nashville, USA., Doebele RC; Department of Medicine, University of Colorado Cancer Center, Aurora, USA.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2019 Feb 01; Vol. 30 (2), pp. 325-331.
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study.
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  Data: <searchLink fieldCode="AU" term="%22Hong+DS%22">Hong DS</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: dshong@mdanderson.org.<br /><searchLink fieldCode="AU" term="%22Bauer+TM%22">Bauer TM</searchLink>; Medical Oncology, Sarah Cannon Research Institute, Tennessee Oncology, PLLC, Nashville, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA.<br /><searchLink fieldCode="AU" term="%22Dowlati+A%22">Dowlati A</searchLink>; Department of Medicine-Hematology and Oncology, UH Cleveland Medical Center, Cleveland, USA.<br /><searchLink fieldCode="AU" term="%22Brose+MS%22">Brose MS</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Farago+AF%22">Farago AF</searchLink>; Department of Medicine, Massachusetts General Hospital, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+M%22">Taylor M</searchLink>; The Knight Cancer Institute, Oregon Health & Science University, Portland, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+AT%22">Shaw AT</searchLink>; Department of Medicine, Massachusetts General Hospital, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Montez+S%22">Montez S</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Meric-Bernstam+F%22">Meric-Bernstam F</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Smith+S%22">Smith S</searchLink>; Loxo Oncology, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Tuch+BB%22">Tuch BB</searchLink>; Loxo Oncology, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Ebata+K%22">Ebata K</searchLink>; Loxo Oncology, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Cruickshank+S%22">Cruickshank S</searchLink>; Loxo Oncology, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Cox+MC%22">Cox MC</searchLink>; Loxo Oncology, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Burris+HA+3rd%22">Burris HA 3rd</searchLink>; Medical Oncology, Sarah Cannon Research Institute, Tennessee Oncology, PLLC, Nashville, USA.<br /><searchLink fieldCode="AU" term="%22Doebele+RC%22">Doebele RC</searchLink>; Department of Medicine, University of Colorado Cancer Center, Aurora, USA.
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  Data: <searchLink fieldCode="JN" term="%229007735%22">Annals of oncology : official journal of the European Society for Medical Oncology</searchLink> [Ann Oncol] 2019 Feb 01; Vol. 30 (2), pp. 325-331.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9007735 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1569-8041 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209237534%22">09237534 </searchLink><i>NLM ISO Abbreviation: </i>Ann Oncol <i>Subsets: </i>MEDLINE
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              Text: 2019 Feb 01
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