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Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut.

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Title: Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut.
Authors: Jiang X; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hall AB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Arthur TD; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Plichta DR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Covington CT; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Poyet M; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Crothers J; Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT 05401, USA., Moses PL; Division of Gastroenterology and Hepatology, University of Vermont, Burlington, VT 05401, USA., Tolonen AC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Alm EJ; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. xavier@molbio.mgh.harvard.edu ejalm@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Xavier RJ; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. xavier@molbio.mgh.harvard.edu ejalm@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Source: Science (New York, N.Y.) [Science] 2019 Jan 11; Vol. 363 (6423), pp. 181-187.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Hall+AB%22">Hall AB</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Arthur+TD%22">Arthur TD</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Plichta+DR%22">Plichta DR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Covington+CT%22">Covington CT</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Poyet+M%22">Poyet M</searchLink>; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Crothers+J%22">Crothers J</searchLink>; Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT 05401, USA.<br /><searchLink fieldCode="AU" term="%22Moses+PL%22">Moses PL</searchLink>; Division of Gastroenterology and Hepatology, University of Vermont, Burlington, VT 05401, USA.<br /><searchLink fieldCode="AU" term="%22Tolonen+AC%22">Tolonen AC</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Vlamakis+H%22">Vlamakis H</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Alm+EJ%22">Alm EJ</searchLink>; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. xavier@molbio.mgh.harvard.edu ejalm@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Xavier+RJ%22">Xavier RJ</searchLink>; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. xavier@molbio.mgh.harvard.edu ejalm@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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