Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
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| Title: | Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. |
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| Authors: | Karlsson Linnér R; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl.; Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands. r.karlssonlinner@vu.nl.; Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl., Biroli P; Department of Economics, University of Zurich, Zurich, Switzerland., Kong E; Department of Economics, Harvard University, Cambridge, MA, USA., Meddens SFW; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands., Wedow R; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Analytic Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Sociology, Harvard University, Cambridge, MA, USA., Fontana MA; Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery, New York, NY, USA.; Department of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York, NY, USA., Lebreton M; Amsterdam School of Economics, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, the Netherlands., Tino SP; Department of Economics, University of Toronto, Toronto, Ontario, Canada., Abdellaoui A; Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Hammerschlag AR; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands., Nivard MG; Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Okbay A; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.; Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands., Rietveld CA; Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Timshel PN; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Trzaskowski M; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Vlaming R; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands., Zünd CL; Department of Economics, University of Zurich, Zurich, Switzerland., Bao Y; Institute for Social and Economic Research, University of Essex, Colchester, UK., Buzdugan L; Seminar for Statistics, Department of Mathematics, ETH Zurich, Zurich, Switzerland.; Department of Economics, University of Zurich, Zurich, Switzerland., Caplin AH; Stuyvesant High School, New York, NY, USA., Chen CY; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Eibich P; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Socio-Economic Panel Study, DIW Berlin, Berlin, Germany.; Max Planck Institute for Demographic Research, Rostock, Germany., Fontanillas P; Research, 23andMe, Inc., Mountain View, CA, USA., Gonzalez JR; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Joshi PK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Karhunen V; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Kleinman A; Research, 23andMe, Inc., Mountain View, CA, USA., Levin RZ; Department of Economics, University of California San Diego, La Jolla, CA, USA., Lill CM; Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany., Meddens GA; Team Loyalty BV, Hoofddorp, the Netherlands., Muntané G; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.; Research Department, Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Reus, Spain., Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Rooij FJV; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Taskesen E; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands., Wu Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Zhang F; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia., Auton A; Research, 23andMe, Inc., Mountain View, CA, USA., Boardman JD; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA.; Department of Sociology, University of Colorado Boulder, Boulder, CO, USA., Clark DW; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Conlin A; Department of Economics and Finance, Oulu Business School, University of Oulu, Oulu, Finland., Dolan CC; Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Fischbacher U; Department of Economics, University of Konstanz, Konstanz, Germany.; Thurgau Institute of Economics, Kreuzlingen, Switzerland., Groenen PJF; Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Department of Econometrics, Erasmus University Rotterdam, Rotterdam, Rotterdam, the Netherlands., Harris KM; Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hasler G; Unit of Psychiatry Research, University of Fribourg, Fribourg, Switzerland., Hofman A; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Jain S; Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, USA., Kooyman M; SURFsara, Amsterdam, the Netherlands., MacKillop J; Peter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.; Homewood Research Institute, Guelph, Ontario, Canada., Männikkö M; Center for Life Course Health Research, University of Oulu, Oulu, Finland., Morcillo-Suarez C; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain., McQueen MB; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Schmidt KM; Department of Economics, University of Munich, Munich, Germany., Smart MC; Institute for Social and Economic Research, University of Essex, Colchester, UK., Sutter M; Department of Economics, University of Cologne, Cologne, Germany.; Experimental Economics Group, Max Planck Institute for Research into Collective Goods, Bonn, Germany.; Department of Public Finance, University of Innsbruck, Innsbruck, Austria., Thurik AR; Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Montpellier Business School, Montpellier, France., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands., White J; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK., Wit H; Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, Australia., Bertram L; Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.; Dept of Psychology, University of Olso, Oslo, Norway.; School of Public Health, Imperial College London, London, UK., Boomsma DI; Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia., Fehr E; Department of Economics, University of Zurich, Zurich, Switzerland., Hinds DA; Research, 23andMe, Inc., Mountain View, CA, USA., Johannesson M; Department of Economics, Stockholm School of Economics, Stockholm, Sweden., Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, UK., Laibson D; Department of Economics, Harvard University, Cambridge, MA, USA., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Meyer MN; Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, PA, USA., Navarro A; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.; Department of Clinical Genetics, VU Medical Centre, Amsterdam, the Netherlands., Schunk D; Department of Economics, Johannes Gutenberg University, Mainz, Germany., Stein MB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA., Svento R; Department of Economics and Finance, Oulu Business School, University of Oulu, Oulu, Finland., Tiemeier H; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Timmers PRHJ; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Turley P; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Behavioral and Health Genomics Center, Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA., Ursano RJ; Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Wagner GG; Socio-Economic Panel Study, DIW Berlin, Berlin, Germany.; Max Planck Institute for Human Development, Berlin, Germany., Wilson JF; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland., Gratten J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.; Mater Medical Research Institute, Translational Research Institute, Brisbane, Australia., Lee JJ; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA., Cesarini D; Department of Economics, New York University, New York, NY, USA., Benjamin DJ; Behavioral and Health Genomics Center, Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.; Department of Economics, University of Southern California, Los Angeles, CA, USA.; National Bureau of Economic Research, Cambridge, MA, USA., Koellinger PD; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.; Department of Economics, VU University Amsterdam, Amsterdam, the Netherlands.; German Institute for Economic Research, DIW Berlin, Berlin, Germany., Beauchamp JP; Department of Economics, University of Toronto, Toronto, Ontario, Canada. jonathan.pierre.beauchamp@gmail.com. |
| Corporate Authors: | 23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium, Social Science Genetic Association Consortium |
| Source: | Nature genetics [Nat Genet] 2019 Feb; Vol. 51 (2), pp. 245-257. Date of Electronic Publication: 2019 Jan 14. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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