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A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

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Title: A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.
Authors: Somers K; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Wen VW; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Middlemiss SMC; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Osborne B; Mitochondrial Bioenergetics Laboratory, School of Medical Sciences, UNSW, Randwick, NSW, Australia., Forgham H; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, UNSW Australia, Sydney, NSW, Australia., Jung M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Karsa M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Clifton M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Bongers A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Gao J; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Mayoh C; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Raoufi-Rad N; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Kusnadi EP; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Hannan KM; The John Curtin School of Medical Research, The Australian National University, Canberra City, ACT, Australia., Scott DA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Kwek A; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Liu B; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Flemming C; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Chudakova DA; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Pandher R; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Failes TW; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ACRF Drug Discovery Centre, Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, New South Wales, Australia., Lim J; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Angeli A; Neurofarba Department, University of Florence, Florence, Italy., Osterman AL; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Imamura T; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kees UR; Telethon Kids Institute, University of Western Australia, Perth, WA, Australia., Supuran CT; Neurofarba Department, University of Florence, Florence, Italy., Pearson RB; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Hannan RD; The John Curtin School of Medical Research, The Australian National University, Canberra City, ACT, Australia., Davis TP; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences, Monash University, Clayton, VIC, Australia.; Department of Chemistry, University of Warrick, Coventry, UK., McCarroll J; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, UNSW Australia, Sydney, NSW, Australia., Kavallaris M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, UNSW Australia, Sydney, NSW, Australia., Turner N; Mitochondrial Bioenergetics Laboratory, School of Medical Sciences, UNSW, Randwick, NSW, Australia., Gudkov AV; Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.; Oncotartis, Inc., Buffalo, NY, USA., Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia., Norris MD; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; UNSW Centre for Childhood Cancer Research, Sydney, NSW, Australia., Henderson MJ; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia. mhenderson@ccia.unsw.edu.au.
Source: Oncogene [Oncogene] 2019 May; Vol. 38 (20), pp. 3824-3842. Date of Electronic Publication: 2019 Jan 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Somers+K%22">Somers K</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wen+VW%22">Wen VW</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Middlemiss+SMC%22">Middlemiss SMC</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Osborne+B%22">Osborne B</searchLink>; Mitochondrial Bioenergetics Laboratory, School of Medical Sciences, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Forgham+H%22">Forgham H</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, UNSW Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Jung+M%22">Jung M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Karsa+M%22">Karsa M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Clifton+M%22">Clifton M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bongers+A%22">Bongers A</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gao+J%22">Gao J</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mayoh+C%22">Mayoh C</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Raoufi-Rad+N%22">Raoufi-Rad N</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kusnadi+EP%22">Kusnadi EP</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hannan+KM%22">Hannan KM</searchLink>; The John Curtin School of Medical Research, The Australian National University, Canberra City, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Scott+DA%22">Scott DA</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Kwek+A%22">Kwek A</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Flemming+C%22">Flemming C</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Chudakova+DA%22">Chudakova DA</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Pandher+R%22">Pandher R</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Failes+TW%22">Failes TW</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ACRF Drug Discovery Centre, Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+J%22">Lim J</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Angeli+A%22">Angeli A</searchLink>; Neurofarba Department, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Osterman+AL%22">Osterman AL</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Imamura+T%22">Imamura T</searchLink>; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kees+UR%22">Kees UR</searchLink>; Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Supuran+CT%22">Supuran CT</searchLink>; Neurofarba Department, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Pearson+RB%22">Pearson RB</searchLink>; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hannan+RD%22">Hannan RD</searchLink>; The John Curtin School of Medical Research, The Australian National University, Canberra City, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Davis+TP%22">Davis TP</searchLink>; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences, Monash University, Clayton, VIC, Australia.; Department of Chemistry, University of Warrick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22McCarroll+J%22">McCarroll J</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, UNSW Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kavallaris+M%22">Kavallaris M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for NanoMedicine, UNSW Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+N%22">Turner N</searchLink>; Mitochondrial Bioenergetics Laboratory, School of Medical Sciences, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gudkov+AV%22">Gudkov AV</searchLink>; Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.; Oncotartis, Inc., Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Haber+M%22">Haber M</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Norris+MD%22">Norris MD</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.; UNSW Centre for Childhood Cancer Research, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Henderson+MJ%22">Henderson MJ</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia. mhenderson@ccia.unsw.edu.au.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2019 May; Vol. 38 (20), pp. 3824-3842. <i>Date of Electronic Publication: </i>2019 Jan 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8711562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5594 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209509232%22">09509232 </searchLink><i>NLM ISO Abbreviation: </i>Oncogene <i>Subsets: </i>MEDLINE
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