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The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models.

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Title: The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models.
Authors: Hicks SW; ImmunoGen Inc., Waltham, MA, USA., Tarantelli C; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland., Wilhem A; ImmunoGen Inc., Waltham, MA, USA., Gaudio E; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland., Li M; ImmunoGen Inc., Waltham, MA, USA., Arribas AJ; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland., Spriano F; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland., Bordone R; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland., Cascione L; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland and., Lai KC; ImmunoGen Inc., Waltham, MA, USA., Qiu Q; ImmunoGen Inc., Waltham, MA, USA., Taborelli M; Cytogenetics Laboratory, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Rossi D; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland., Stussi G; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland., Zucca E; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland., Stathis A; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland., Sloss CM; ImmunoGen Inc., Waltham, MA, USA frbertoni@mac.com callum.sloss@immunogen.com., Bertoni F; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland frbertoni@mac.com callum.sloss@immunogen.com.
Source: Haematologica [Haematologica] 2019 Aug; Vol. 104 (8), pp. 1633-1639. Date of Electronic Publication: 2019 Feb 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models.
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  Data: <searchLink fieldCode="AU" term="%22Hicks+SW%22">Hicks SW</searchLink>; ImmunoGen Inc., Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tarantelli+C%22">Tarantelli C</searchLink>; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wilhem+A%22">Wilhem A</searchLink>; ImmunoGen Inc., Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gaudio+E%22">Gaudio E</searchLink>; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; ImmunoGen Inc., Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Arribas+AJ%22">Arribas AJ</searchLink>; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Spriano+F%22">Spriano F</searchLink>; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bordone+R%22">Bordone R</searchLink>; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cascione+L%22">Cascione L</searchLink>; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland and.<br /><searchLink fieldCode="AU" term="%22Lai+KC%22">Lai KC</searchLink>; ImmunoGen Inc., Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+Q%22">Qiu Q</searchLink>; ImmunoGen Inc., Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Taborelli+M%22">Taborelli M</searchLink>; Cytogenetics Laboratory, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rossi+D%22">Rossi D</searchLink>; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland.; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stussi+G%22">Stussi G</searchLink>; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zucca+E%22">Zucca E</searchLink>; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stathis+A%22">Stathis A</searchLink>; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sloss+CM%22">Sloss CM</searchLink>; ImmunoGen Inc., Waltham, MA, USA frbertoni@mac.com callum.sloss@immunogen.com.<br /><searchLink fieldCode="AU" term="%22Bertoni+F%22">Bertoni F</searchLink>; Università della Svizzera italiana, Institute of Oncology Research, Bellinzona, Switzerland frbertoni@mac.com callum.sloss@immunogen.com.
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  Data: <searchLink fieldCode="JN" term="%220417435%22">Haematologica</searchLink> [Haematologica] 2019 Aug; Vol. 104 (8), pp. 1633-1639. <i>Date of Electronic Publication: </i>2019 Feb 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE
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