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Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors.

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Title: Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors.
Authors: Längle D; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany.; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-Universität Kiel, Gutenbergstr. 76, 24118, Kiel, Germany., Werner TR; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany., Wesseler F; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany., Reckzeh E; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany., Schaumann N; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany., Drowley L; Cardiovascular, Renal and Metabolic Diseases IMED Biotech Unit, AstraZeneca Gothenburg, Pepparsleden 1, 43 183, Mölndal, Sweden., Polla M; Cardiovascular, Renal and Metabolic Diseases IMED Biotech Unit, AstraZeneca Gothenburg, Pepparsleden 1, 43 183, Mölndal, Sweden., Plowright AT; Cardiovascular, Renal and Metabolic Diseases IMED Biotech Unit, AstraZeneca Gothenburg, Pepparsleden 1, 43 183, Mölndal, Sweden., Hirt MN; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany., Eschenhagen T; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany., Schade D; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany.; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-Universität Kiel, Gutenbergstr. 76, 24118, Kiel, Germany.
Source: ChemMedChem [ChemMedChem] 2019 Apr 17; Vol. 14 (8), pp. 810-822. Date of Electronic Publication: 2019 Feb 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Längle+D%22">Längle D</searchLink>; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany.; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-Universität Kiel, Gutenbergstr. 76, 24118, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Werner+TR%22">Werner TR</searchLink>; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wesseler+F%22">Wesseler F</searchLink>; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Reckzeh+E%22">Reckzeh E</searchLink>; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Schaumann+N%22">Schaumann N</searchLink>; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Drowley+L%22">Drowley L</searchLink>; Cardiovascular, Renal and Metabolic Diseases IMED Biotech Unit, AstraZeneca Gothenburg, Pepparsleden 1, 43 183, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Polla+M%22">Polla M</searchLink>; Cardiovascular, Renal and Metabolic Diseases IMED Biotech Unit, AstraZeneca Gothenburg, Pepparsleden 1, 43 183, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Plowright+AT%22">Plowright AT</searchLink>; Cardiovascular, Renal and Metabolic Diseases IMED Biotech Unit, AstraZeneca Gothenburg, Pepparsleden 1, 43 183, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Hirt+MN%22">Hirt MN</searchLink>; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Eschenhagen+T%22">Eschenhagen T</searchLink>; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schade+D%22">Schade D</searchLink>; Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 4, 44227, Dortmund, Germany.; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-Universität Kiel, Gutenbergstr. 76, 24118, Kiel, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101259013%22">ChemMedChem</searchLink> [ChemMedChem] 2019 Apr 17; Vol. 14 (8), pp. 810-822. <i>Date of Electronic Publication: </i>2019 Feb 28.
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