A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
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| Title: | A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. |
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| Authors: | Schewe M; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de., Sun H; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Structural Biology, 13125 Berlin, Germany., Mert Ü; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Mackenzie A; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Pike ACW; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK., Schulz F; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Constantin C; Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.; Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany., Vowinkel KS; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany., Conrad LJ; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Kiper AK; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany., Gonzalez W; Centro de Bioinformatica y Simulacion Molecular, Universidad de Talca, 3465548 Talca, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, 3465548 Talca, Chile., Musinszki M; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Tegtmeier M; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Pryde DC; Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, UK., Belabed H; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany., Nazare M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany., de Groot BL; Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany., Decher N; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany., Fakler B; Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.; Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany., Carpenter EP; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK., Tucker SJ; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Baukrowitz T; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de. |
| Source: | Science (New York, N.Y.) [Science] 2019 Feb 22; Vol. 363 (6429), pp. 875-880. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aav0569 |
