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A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.

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Title: A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Authors: Schewe M; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de., Sun H; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Structural Biology, 13125 Berlin, Germany., Mert Ü; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Mackenzie A; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Pike ACW; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK., Schulz F; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Constantin C; Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.; Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany., Vowinkel KS; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany., Conrad LJ; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Kiper AK; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany., Gonzalez W; Centro de Bioinformatica y Simulacion Molecular, Universidad de Talca, 3465548 Talca, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, 3465548 Talca, Chile., Musinszki M; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Tegtmeier M; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany., Pryde DC; Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, UK., Belabed H; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany., Nazare M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany., de Groot BL; Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany., Decher N; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany., Fakler B; Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.; Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany., Carpenter EP; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK., Tucker SJ; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK., Baukrowitz T; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de.
Source: Science (New York, N.Y.) [Science] 2019 Feb 22; Vol. 363 (6429), pp. 875-880.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science
Database: MEDLINE Ultimate
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  Data: A pharmacological master key mechanism that unlocks the selectivity filter gate in K<superscript>+</superscript> channels.
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  Data: <searchLink fieldCode="AU" term="%22Schewe+M%22">Schewe M</searchLink>; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Structural Biology, 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mert+Ü%22">Mert Ü</searchLink>; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Mackenzie+A%22">Mackenzie A</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.<br /><searchLink fieldCode="AU" term="%22Pike+ACW%22">Pike ACW</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.<br /><searchLink fieldCode="AU" term="%22Schulz+F%22">Schulz F</searchLink>; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Constantin+C%22">Constantin C</searchLink>; Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.; Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vowinkel+KS%22">Vowinkel KS</searchLink>; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Conrad+LJ%22">Conrad LJ</searchLink>; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.<br /><searchLink fieldCode="AU" term="%22Kiper+AK%22">Kiper AK</searchLink>; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gonzalez+W%22">Gonzalez W</searchLink>; Centro de Bioinformatica y Simulacion Molecular, Universidad de Talca, 3465548 Talca, Chile.; Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, 3465548 Talca, Chile.<br /><searchLink fieldCode="AU" term="%22Musinszki+M%22">Musinszki M</searchLink>; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Tegtmeier+M%22">Tegtmeier M</searchLink>; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Pryde+DC%22">Pryde DC</searchLink>; Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, UK.<br /><searchLink fieldCode="AU" term="%22Belabed+H%22">Belabed H</searchLink>; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Nazare+M%22">Nazare M</searchLink>; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Medicinal Chemistry, 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22de+Groot+BL%22">de Groot BL</searchLink>; Computational Biomolecular Dynamics Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Decher+N%22">Decher N</searchLink>; Institute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, 35037 Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fakler+B%22">Fakler B</searchLink>; Institute of Physiology II, Albert-Ludwigs University of Freiburg, 79104 Freiburg, Germany.; Centers for Biological Signaling Studies CIBSS and BIOSS, 79104 Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Carpenter+EP%22">Carpenter EP</searchLink>; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.<br /><searchLink fieldCode="AU" term="%22Tucker+SJ%22">Tucker SJ</searchLink>; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.<br /><searchLink fieldCode="AU" term="%22Baukrowitz+T%22">Baukrowitz T</searchLink>; Institute of Physiology, Christian-Albrechts University of Kiel, 24118 Kiel, Germany. m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de.
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