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A Novel Na+-K+-Cl- Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke.

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Title: A Novel Na+-K+-Cl- Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke.
Authors: Huang H; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Department of Neurology, First Affiliate Hospital, Harbin Medical University, Heilongjiang, China (H.H., Z.Z.)., Bhuiyan MIH; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA., Jiang T; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA., Song S; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA., Shankar S; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA., Taheri T; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA., Li E; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA., Schreppel P; Department of Pharmaceutical Chemistry, University of Vienna, Austria (P.S., M.H., T.E.)., Hintersteininger M; Department of Pharmaceutical Chemistry, University of Vienna, Austria (P.S., M.H., T.E.)., Yang SS; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (S.-S.Y., S.-H.L.)., Lin SH; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (S.-S.Y., S.-H.L.)., Molyneaux BJ; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA., Zhang Z; Department of Neurology, First Affiliate Hospital, Harbin Medical University, Heilongjiang, China (H.H., Z.Z.)., Erker T; Department of Pharmaceutical Chemistry, University of Vienna, Austria (P.S., M.H., T.E.)., Sun D; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.
Source: Stroke [Stroke] 2019 Apr; Vol. 50 (4), pp. 1021-1025.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Novel Na<superscript>+</superscript>-K<superscript>+</superscript>-Cl<superscript>-</superscript> Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke.
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  Data: <searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Department of Neurology, First Affiliate Hospital, Harbin Medical University, Heilongjiang, China (H.H., Z.Z.).<br /><searchLink fieldCode="AU" term="%22Bhuiyan+MIH%22">Bhuiyan MIH</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Jiang+T%22">Jiang T</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Song+S%22">Song S</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Shankar+S%22">Shankar S</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Taheri+T%22">Taheri T</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Li+E%22">Li E</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Schreppel+P%22">Schreppel P</searchLink>; Department of Pharmaceutical Chemistry, University of Vienna, Austria (P.S., M.H., T.E.).<br /><searchLink fieldCode="AU" term="%22Hintersteininger+M%22">Hintersteininger M</searchLink>; Department of Pharmaceutical Chemistry, University of Vienna, Austria (P.S., M.H., T.E.).<br /><searchLink fieldCode="AU" term="%22Yang+SS%22">Yang SS</searchLink>; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (S.-S.Y., S.-H.L.).<br /><searchLink fieldCode="AU" term="%22Lin+SH%22">Lin SH</searchLink>; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (S.-S.Y., S.-H.L.).<br /><searchLink fieldCode="AU" term="%22Molyneaux+BJ%22">Molyneaux BJ</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Neurology, First Affiliate Hospital, Harbin Medical University, Heilongjiang, China (H.H., Z.Z.).<br /><searchLink fieldCode="AU" term="%22Erker+T%22">Erker T</searchLink>; Department of Pharmaceutical Chemistry, University of Vienna, Austria (P.S., M.H., T.E.).<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; From the Department of Neurology (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.; Pittsburgh Institute for Neurodegenerative Disorders (H.H., M.I.H.B., T.J., S. Song, S. Shankar, T.T., E.L., B.J.M, D.S.), University of Pittsburgh, PA.
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  Data: <searchLink fieldCode="JN" term="%220235266%22">Stroke</searchLink> [Stroke] 2019 Apr; Vol. 50 (4), pp. 1021-1025.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0235266 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1524-4628 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200392499%22">00392499 </searchLink><i>NLM ISO Abbreviation: </i>Stroke <i>Subsets: </i>MEDLINE
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        Value: 10.1161/STROKEAHA.118.024287
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      – Code: eng
        Text: English
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        StartPage: 1021
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      – TitleFull: A Novel Na+-K+-Cl- Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke.
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              M: 04
              Text: 2019 Apr
              Type: published
              Y: 2019
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