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Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

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Title: Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
Authors: Basheer F; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Giotopoulos G; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Meduri E; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Yun H; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Mazan M; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Sasca D; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Gallipoli P; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Marando L; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Gozdecka M; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Asby R; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Sheppard O; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK., Dudek M; Wellcome Trust Sanger Institute, Hinxton, UK., Bullinger L; Charité University Hospital, Berlin, Germany., Döhner H; Department of Internal Medicine III, University of Ulm, Ulm, Germany., Dillon R; Department of Medical and Molecular Genetics, Kings College School of Medicine, UK., Freeman S; Department of Clinical Immunology, University of Birmingham Medical School, Edgbaston, Birmingham, UK., Ottmann O; Department of Haematology, University of Cardiff, Cardiff, UK., Burnett A; Isle of Arran, UK., Russell N; Department of Haematology, University of Nottingham, Nottingham, UK., Papaemmanuil E; Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan-Kettering Cancer Center, New York, NY., Hills R; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Campbell P; Wellcome Trust Sanger Institute, Hinxton, UK., Vassiliou GS; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Huntly BJP; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK bjph2@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.
Source: The Journal of experimental medicine [J Exp Med] 2019 Apr 01; Vol. 216 (4), pp. 966-981. Date of Electronic Publication: 2019 Mar 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
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  Data: <searchLink fieldCode="AU" term="%22Basheer+F%22">Basheer F</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Giotopoulos+G%22">Giotopoulos G</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Meduri+E%22">Meduri E</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Yun+H%22">Yun H</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mazan+M%22">Mazan M</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Sasca+D%22">Sasca D</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gallipoli+P%22">Gallipoli P</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Marando+L%22">Marando L</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Asby+R%22">Asby R</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sheppard+O%22">Sheppard O</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dudek+M%22">Dudek M</searchLink>; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Bullinger+L%22">Bullinger L</searchLink>; Charité University Hospital, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Döhner+H%22">Döhner H</searchLink>; Department of Internal Medicine III, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Dillon+R%22">Dillon R</searchLink>; Department of Medical and Molecular Genetics, Kings College School of Medicine, UK.<br /><searchLink fieldCode="AU" term="%22Freeman+S%22">Freeman S</searchLink>; Department of Clinical Immunology, University of Birmingham Medical School, Edgbaston, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Ottmann+O%22">Ottmann O</searchLink>; Department of Haematology, University of Cardiff, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Burnett+A%22">Burnett A</searchLink>; Isle of Arran, UK.<br /><searchLink fieldCode="AU" term="%22Russell+N%22">Russell N</searchLink>; Department of Haematology, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Papaemmanuil+E%22">Papaemmanuil E</searchLink>; Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan-Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Hills+R%22">Hills R</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+P%22">Campbell P</searchLink>; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Huntly+BJP%22">Huntly BJP</searchLink>; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK bjph2@cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.
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