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mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.

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Title: mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.
Authors: Tang H; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Inoki K; Life Science Institute, University of Michigan, Ann Arbor, Michigan.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Brooks SV; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Okazawa H; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, California., Lee M; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Wang J; Life Science Institute, University of Michigan, Ann Arbor, Michigan., Kim M; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Kennedy CL; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Macpherson PCD; Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan., Ji X; Human Immune Monitoring Center, Stanford University School of Medicine, Stanford, California., Van Roekel S; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan., Fraga DA; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Wang K; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Zhu J; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Wang Y; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California., Sharp ZD; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas., Miller RA; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan., Rando TA; VA Palo Alto Healthcare System, Palo Alto, California.; Paul F. Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California., Goldman D; Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan., Guan KL; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, California., Shrager JB; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.
Source: Aging cell [Aging Cell] 2019 Jun; Vol. 18 (3), pp. e12943. Date of Electronic Publication: 2019 Mar 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.
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  Data: <searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Inoki+K%22">Inoki K</searchLink>; Life Science Institute, University of Michigan, Ann Arbor, Michigan.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Brooks+SV%22">Brooks SV</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Okazawa+H%22">Okazawa H</searchLink>; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Lee+M%22">Lee M</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Life Science Institute, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Kennedy+CL%22">Kennedy CL</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Macpherson+PCD%22">Macpherson PCD</searchLink>; Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Ji+X%22">Ji X</searchLink>; Human Immune Monitoring Center, Stanford University School of Medicine, Stanford, California.<br /><searchLink fieldCode="AU" term="%22Van+Roekel+S%22">Van Roekel S</searchLink>; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Fraga+DA%22">Fraga DA</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Sharp+ZD%22">Sharp ZD</searchLink>; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Miller+RA%22">Miller RA</searchLink>; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Rando+TA%22">Rando TA</searchLink>; VA Palo Alto Healthcare System, Palo Alto, California.; Paul F. Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.<br /><searchLink fieldCode="AU" term="%22Goldman+D%22">Goldman D</searchLink>; Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Guan+KL%22">Guan KL</searchLink>; Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Shrager+JB%22">Shrager JB</searchLink>; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.; VA Palo Alto Healthcare System, Palo Alto, California.
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  Data: <searchLink fieldCode="JN" term="%22101130839%22">Aging cell</searchLink> [Aging Cell] 2019 Jun; Vol. 18 (3), pp. e12943. <i>Date of Electronic Publication: </i>2019 Mar 29.
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