Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells.

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Title: Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells.
Authors: Sak M; Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, 40202, USA.; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, 40202, USA., Zumbar CT; Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, 40202, USA., King PD; The Department of Pathology, Ohio State University, Columbus, OH, 43212, USA., Li X; The Department of Pathology, Ohio State University, Columbus, OH, 43212, USA., Mifsud CS; The Department of Pathology, Ohio State University, Columbus, OH, 43212, USA., Usubalieva A; The Department of Pathology, Ohio State University, Columbus, OH, 43212, USA., Anderson CD; Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, 40202, USA., Chesnick HM; The Department of Pathology, Ohio State University, Columbus, OH, 43212, USA., McElroy JP; Department of Biomedical Informatics, Ohio State University, Columbus, OH, 43212, USA., Chakravarti A; Department of Radiation Oncology, Ohio State University, Columbus, OH, 43212, USA., Burton EC; Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Lehman NL; Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, 40202, USA. nllehman1@gmail.com.; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY, 40202, USA. nllehman1@gmail.com.; The Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA. nllehman1@gmail.com.
Source: Journal of neuro-oncology [J Neurooncol] 2019 Jun; Vol. 143 (2), pp. 231-240. Date of Electronic Publication: 2019 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-7373
DOI:10.1007/s11060-019-03164-5