Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.
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| Title: | Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis. |
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| Authors: | Ma Y; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA., Baltezor M; Lead Development Optimization Shared Resource, University of Kansas Cancer Center, Biotechnology Innovation and Optimization Center, Lawrence, KS, USA.; Institute for Advancing Medical Innovation, University of Kansas Medical Center, Kansas City, KS, USA., Rajewski L; Lead Development Optimization Shared Resource, University of Kansas Cancer Center, Biotechnology Innovation and Optimization Center, Lawrence, KS, USA., Crow J; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA., Samuel G; Division of Hematology/Oncology, Children's Mercy Kansas City, Kansas City, MO, USA., Staggs VS; Health Services & Outcomes Research, Children's Mercy Kansas City and School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA., Chastain KM; Division of Hematology/Oncology, Children's Mercy Kansas City, Kansas City, MO, USA., Toretsky JA; Department of Oncology, Georgetown University Medical Center, Washington, D.C., USA., Weir SJ; Institute for Advancing Medical Innovation, University of Kansas Medical Center, Kansas City, KS, USA.; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA., Godwin AK; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA. agodwin@kumc.edu.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA. agodwin@kumc.edu. |
| Source: | Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2019 Jul; Vol. 97 (7), pp. 957-972. Date of Electronic Publication: 2019 Apr 25. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1440 (Electronic) Linking ISSN: 09462716 NLM ISO Abbreviation: J Mol Med (Berl) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 31025088 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Baltezor+M%22">Baltezor M</searchLink>; Lead Development Optimization Shared Resource, University of Kansas Cancer Center, Biotechnology Innovation and Optimization Center, Lawrence, KS, USA.; Institute for Advancing Medical Innovation, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Rajewski+L%22">Rajewski L</searchLink>; Lead Development Optimization Shared Resource, University of Kansas Cancer Center, Biotechnology Innovation and Optimization Center, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Crow+J%22">Crow J</searchLink>; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Samuel+G%22">Samuel G</searchLink>; Division of Hematology/Oncology, Children's Mercy Kansas City, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Staggs+VS%22">Staggs VS</searchLink>; Health Services & Outcomes Research, Children's Mercy Kansas City and School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Chastain+KM%22">Chastain KM</searchLink>; Division of Hematology/Oncology, Children's Mercy Kansas City, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Toretsky+JA%22">Toretsky JA</searchLink>; Department of Oncology, Georgetown University Medical Center, Washington, D.C., USA.<br /><searchLink fieldCode="AU" term="%22Weir+SJ%22">Weir SJ</searchLink>; Institute for Advancing Medical Innovation, University of Kansas Medical Center, Kansas City, KS, USA.; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Godwin+AK%22">Godwin AK</searchLink>; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA. agodwin@kumc.edu.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA. agodwin@kumc.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229504370%22">Journal of molecular medicine (Berlin, Germany)</searchLink> [J Mol Med (Berl)] 2019 Jul; Vol. 97 (7), pp. 957-972. <i>Date of Electronic Publication: </i>2019 Apr 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9504370 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1440 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209462716%22">09462716 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Med (Berl) <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=31025088 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00109-019-01782-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 957 Titles: – TitleFull: Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ma Y – PersonEntity: Name: NameFull: Baltezor M – PersonEntity: Name: NameFull: Rajewski L – PersonEntity: Name: NameFull: Crow J – PersonEntity: Name: NameFull: Samuel G – PersonEntity: Name: NameFull: Staggs VS – PersonEntity: Name: NameFull: Chastain KM – PersonEntity: Name: NameFull: Toretsky JA – PersonEntity: Name: NameFull: Weir SJ – PersonEntity: Name: NameFull: Godwin AK IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2019 Jul Type: published Y: 2019 Identifiers: – Type: issn-electronic Value: 1432-1440 Numbering: – Type: volume Value: 97 – Type: issue Value: 7 Titles: – TitleFull: Journal of molecular medicine (Berlin, Germany) Type: main |
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