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Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.

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Title: Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.
Authors: Sachs J; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany., Döhl K; Institute of Biochemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Weber A; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Jülich, Germany., Bonus M; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Ehlers F; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany., Fleischer E; MicroCombiChem GmbH, Wiesbaden, Germany., Klinger A; MicroCombiChem GmbH, Wiesbaden, Germany., Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.; John von Neumann Institute for Computing, Jülich Supercomputing Centre and Institute for Complex Systems - Structural Biochemistry, Forschungszentrum Jülich GmbH, Jülich, Germany., Pietruszka J; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Jülich, Germany.; IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich, Germany., Schmitt L; Institute of Biochemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Teusch N; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany.
Source: Frontiers in pharmacology [Front Pharmacol] 2019 Apr 16; Vol. 10, pp. 400. Date of Electronic Publication: 2019 Apr 16 (Print Publication: 2019).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.
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  Data: <searchLink fieldCode="AU" term="%22Sachs+J%22">Sachs J</searchLink>; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany.<br /><searchLink fieldCode="AU" term="%22Döhl+K%22">Döhl K</searchLink>; Institute of Biochemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+A%22">Weber A</searchLink>; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Bonus+M%22">Bonus M</searchLink>; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Ehlers+F%22">Ehlers F</searchLink>; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany.<br /><searchLink fieldCode="AU" term="%22Fleischer+E%22">Fleischer E</searchLink>; MicroCombiChem GmbH, Wiesbaden, Germany.<br /><searchLink fieldCode="AU" term="%22Klinger+A%22">Klinger A</searchLink>; MicroCombiChem GmbH, Wiesbaden, Germany.<br /><searchLink fieldCode="AU" term="%22Gohlke+H%22">Gohlke H</searchLink>; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.; John von Neumann Institute for Computing, Jülich Supercomputing Centre and Institute for Complex Systems - Structural Biochemistry, Forschungszentrum Jülich GmbH, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Pietruszka+J%22">Pietruszka J</searchLink>; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Jülich, Germany.; IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitt+L%22">Schmitt L</searchLink>; Institute of Biochemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Teusch+N%22">Teusch N</searchLink>; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2019 Apr 16; Vol. 10, pp. 400. <i>Date of Electronic Publication: </i>2019 Apr 16 (<i>Print Publication: </i>2019).
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